CAJ | 학술논문

目的：比较2型糖尿病合并代谢综合征患者及2型糖尿病无代谢综合征患者体内脂联素、内脏脂肪组织源性丝氨酸蛋白酶抑制剂、IL-6的水平，探讨ADP、丝氨酸蛋白酶抑制剂、IL-6与代谢综合征的关系。方法68例新诊断T2DM患者分成两组：2型糖尿病合并代谢综合征组（M组）51例及2型糖尿病无代谢综合征组（F组）17例。测定各组空腹血清IL-6、脂联素、内脏脂肪组织源性丝氨酸蛋白酶抑制剂、血糖、血脂、糖化血红蛋白（HbA1C）、胰岛素（INS）、胰岛素抵抗水平（HOMA-IR）、体质量（BMI）、腰臀比（W/H）等。结果 M组BMI、HbA1c、空腹血糖（FBG）、空腹胰岛素（FINS），胰岛素抵抗（HOMA-IR），甘油三酯（TG）、总胆固醇（TC）、血管收缩压（SBP）等水平显著高于F组（P<0.05或0.01）。M组的IL-6显著高于F组，脂联素显著低于F组。丝氨酸蛋白酶抑制剂两组间无显著差异。脂联素与TG（r=-0.30，P=0.02）呈明显正相关，与BMI（r=-0.47，P=0.39）、HOMA-IR（r=-0.30，P=0.03)呈明显负相关（P<0.05）。vaspin与HOMA-IR（r=0.347，P=0.02）呈明显正相关（P<0.05），与HDL-L（r=-0.45，P=0.01）呈明显负相关（P<0.05）。IL-6与LDL-L（r=0.54，P=0.00）呈明显正相关（P<0.05），与HDL-L（r=-0.45，P=0.01）呈明显负相关（P<0.05）。结论血清脂联素、IL-6浓度与代谢综合征密切相关，丝氨酸蛋白酶抑制剂与代谢综合征的关系尚待研究。
목적：비교2형당뇨병합병대사종합정환자급2형당뇨병무대사종합정환자체내지련소、내장지방조직원성사안산단백매억제제、IL-6적수평，탐토ADP、사안산단백매억제제、IL-6여대사종합정적관계。방법68례신진단T2DM환자분성량조：2형당뇨병합병대사종합정조（M조）51례급2형당뇨병무대사종합정조（F조）17례。측정각조공복혈청IL-6、지련소、내장지방조직원성사안산단백매억제제、혈당、혈지、당화혈홍단백（HbA1C）、이도소（INS）、이도소저항수평（HOMA-IR）、체질량（BMI）、요둔비（W/H）등。결과 M조BMI、HbA1c、공복혈당（FBG）、공복이도소（FINS），이도소저항（HOMA-IR），감유삼지（TG）、총담고순（TC）、혈관수축압（SBP）등수평현저고우F조（P<0.05혹0.01）。M조적IL-6현저고우F조，지련소현저저우F조。사안산단백매억제제량조간무현저차이。지련소여TG（r=-0.30，P=0.02）정명현정상관，여BMI（r=-0.47，P=0.39）、HOMA-IR（r=-0.30，P=0.03)정명현부상관（P<0.05）。vaspin여HOMA-IR（r=0.347，P=0.02）정명현정상관（P<0.05），여HDL-L（r=-0.45，P=0.01）정명현부상관（P<0.05）。IL-6여LDL-L（r=0.54，P=0.00）정명현정상관（P<0.05），여HDL-L（r=-0.45，P=0.01）정명현부상관（P<0.05）。결론혈청지련소、IL-6농도여대사종합정밀절상관，사안산단백매억제제여대사종합정적관계상대연구。
Objective To study the correlation between adipocytokines levels and metabolic syndrome (MS) in patients with newly diagnosed type 2 diabetes mellitus (T2DM). Methods Sixty-eight patients with newly diagnosed T2DM, including 51 cases with MS and 17 without MS, were examined for blood pressure (BP), fasting blood glucose (FBG), fasting insulin (FINS), insulin resistance index (IRI), waist to hip ratio (W/H), body mass index (BMI), and serum dipocytokine levels (IL-6, vaspin, and adiponectin). Results The diabeitc patients with MS had higher BMI, HbA1c, FBG, FINS, IRI, TG, TC, and SBP than those without MS. Serum IL-6 level was higher but adiponectin level was lower in patients with MS than in those without MS. There was no significant difference in vispin level between the two groups. Adiponectin level was positively correlated with TG (r=-0.30, P=0.02) and inversely with BMI (r=-0.47, P=0.39) and HOMA-IR (r=-0.30, P=0.03); vispin level was positively correlated with HOMA-IR (r=0.347, P=0.02) and inversely with HDL-L (r=-0.45, P=0.01);IL-6 level was positively correlated with LDL-L (r=0.18, P=0.25) and inversely with HDL-L (r=-0.45, P=0.01). Conclusion Adiponectin and IL-6 levels are closely related to MS, but the relationship between vispin and MS needs further invesitgation.