CAJ | 학술논문

目的：探讨控制性卵巢刺激周期中，取卵日卵泡液hCG水平与获卵数、卵母细胞成熟率、胚胎发育和妊娠结局的关系。方法分析2012~2013年间进行的311个IVF/ICSI-ET周期，化学发光法检测取卵日卵泡液hCG值，并根据hCG值进行分组，比较各组获卵数、卵母细胞成熟率、受精率、卵裂率、可利用胚胎率和临床妊娠率的差异。结果在IVF/ICSI-ET治疗周期中，取卵日hCG水平14~21 nmol/L组卵母细胞成熟率和受精率显著高于其它各组（P<0.05），获卵数、卵裂率、可利用胚胎率以及临床妊娠率与其它各组相比较高，但不存在显著差异（P>0.05）。取卵日hCG水平>21 nmol/L组卵母细胞成熟率和受精率显著低于其它各组（P<0.05），可利用胚胎率和临床妊娠率与其它各组相比较低，但不存在显著差异（P>0.05）。结论取卵日卵泡液hCG水平与卵母细胞成熟率、受精能力、胚胎发育潜能和最终的临床结局相关，取卵日卵泡液hCG水平过高可能不利于卵母细胞成熟和胚胎发育。
목적：탐토공제성란소자격주기중，취란일란포액hCG수평여획란수、란모세포성숙솔、배태발육화임신결국적관계。방법분석2012~2013년간진행적311개IVF/ICSI-ET주기，화학발광법검측취란일란포액hCG치，병근거hCG치진행분조，비교각조획란수、란모세포성숙솔、수정솔、란렬솔、가이용배태솔화림상임신솔적차이。결과재IVF/ICSI-ET치료주기중，취란일hCG수평14~21 nmol/L조란모세포성숙솔화수정솔현저고우기타각조（P<0.05），획란수、란렬솔、가이용배태솔이급림상임신솔여기타각조상비교고，단불존재현저차이（P>0.05）。취란일hCG수평>21 nmol/L조란모세포성숙솔화수정솔현저저우기타각조（P<0.05），가이용배태솔화림상임신솔여기타각조상비교저，단불존재현저차이（P>0.05）。결론취란일란포액hCG수평여란모세포성숙솔、수정능력、배태발육잠능화최종적림상결국상관，취란일란포액hCG수평과고가능불리우란모세포성숙화배태발육。
Objective To explore the correlation of human chorionic gonadotrophin (hCG) level in the follicular fluid on oocyte retrieval day with the number of oocytes retrieved, maturation rate, embryonic development, and pregnancy outcome in controlled ovarian stimulation cycles. Methods The data of 311 IVF/ICSI-ET cycles from 2012 to 2013 was analyzed and stratified according to hCG level in follicular fluid on oocyte retrieval day (<7 nmol/L, 7-14 nmol/L, 14-21 nmol/L, and >21 nmol/L) determined with chemiluminesence method. The number of oocytes retrieved, oocyte maturation rate, fertilization rate, cleavage rate, available embryo rate and pregnancy rate were compared between the groups. Results In the IVF/ICSI-ET cycles, the cycles with hCG level of 14-21 nmol/L in the follicular fluid on the day of oocyte retrieval had significantly higher oocyte maturation rate and fertilization rate than those in the other 3 groups (P<0.05), but the number of oocytes retrieved, cleavage rate, available embryo rate and pregnancy rate, though slightly higher, showed no significant difference from the other 3 groups (P>0.05). In the group with hCG level >21 nmol/L, the oocyte maturation rate and fertilization rate were significantly lower than those in the other 3 groups (P<0.05), and the available embryo rate and pregnancy rate were slightly lower without significant differences from the other 3 groups (P>0.05). Conclusion Follicular fluid hCG level on the day of oocyte retrieval is associated with oocyte maturation, fertilization, embryonic development potential, and IVF outcome. An excessively high follicular fluid hCG level on the day of oocyte retrieval may have negative effects on oocyte maturation and embryo development.