CAJ | 학술논문

目的：本研究探讨吉非替尼联合鸦胆子油乳二线对晚期NSCLC的疗效的影响。方法：将58例晚期NSCLC随机分为两组，每组29例，所有研究对象均给予吉非替尼，治疗组在对照组的基础上加用鸦胆子油乳，所有患者每月随访复查一次，比较两组的临床疗效和安全性以及生存资料的资料。结果：治疗组的临床疗效疾病控制率为79.3%，明显优于对照组58.6%，两组差异有统计学意义(P<0.05)；治疗组疾病中位PFS为11个月；对照组的PFS为6个月；治疗组中位生存时间(MST)为17个月；对照组的MST为12个月；两组的不良反应是骨髓抑制及消化道反应，治疗组好于对照组；并能改善治疗组KSP评分，故和常规放化疗比较，不良反应程度较轻。结论：吉非替尼联合鸦胆子治疗老年晚期NSCLC患者，其疗效较好，能提高患者生存率，有明显的生存疗效；因其不良反应少，患者有较好的耐受性，故值得临床推广。
목적：본연구탐토길비체니연합아담자유유이선대만기NSCLC적료효적영향。방법：장58례만기NSCLC수궤분위량조，매조29례，소유연구대상균급여길비체니，치료조재대조조적기출상가용아담자유유，소유환자매월수방복사일차，비교량조적림상료효화안전성이급생존자료적자료。결과：치료조적림상료효질병공제솔위79.3%，명현우우대조조58.6%，량조차이유통계학의의(P<0.05)；치료조질병중위PFS위11개월；대조조적PFS위6개월；치료조중위생존시간(MST)위17개월；대조조적MST위12개월；량조적불량반응시골수억제급소화도반응，치료조호우대조조；병능개선치료조KSP평분，고화상규방화료비교，불량반응정도교경。결론：길비체니연합아담자치료노년만기NSCLC환자，기료효교호，능제고환자생존솔，유명현적생존료효；인기불량반응소，환자유교호적내수성，고치득림상추엄。
objective:The aim of this study is to explore the effects and safety of Gefitinib and Brucea javanica oil emulsion (BJOE) on patients with advanced NSCLC . Methods:58 advanced NSCLC patients were randomly divided into two groups ,the contol group (n=29) and the treatment group(n=29);All patients were given Gefitinib;the treatment group were given Brucea javanica oil emulsionas anti-tumor therapy as well. All the patients were followed monthly review once, compared two groups of clinical curative effect and security, and survival data information. Results:after treatment, the disease control rate of treatment group was 79.3%, is obviously better than that of the control group which was 58.6%.For the treatment groups, median survival time was 17 months,median progression-free survival (mPFS) was 11 months,In the control group, median survival time was 12 months, median progression-free survival (mPFS) was 6 months, there was a significandifference(P<0.05).And the most common adverse reactions were neutropenia and digestive tract reaction;improved the KFS score of the treatment group and the adverse reaction was lighter. Conclusion:the gefitinib and Brucea javanica oil emulsion were effective in treating advanced NSCLC,can improve dsurvival rate,reduce the level of tumor markers;because of few side effects and well tolerance,It is worth expanding the clinical usage of the preparation.