浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2014年
3期
208-212,221
,共6页
精神分裂症%齐拉西酮%奥氮平%疗效%安全性%Meta分析
精神分裂癥%齊拉西酮%奧氮平%療效%安全性%Meta分析
정신분렬증%제랍서동%오담평%료효%안전성%Meta분석
Schizophrenia%Ziprasidone%Olanzapine%Efficacy Safety%Meta analysis
目的评价齐拉西酮与奥氮平治疗精神分裂症对照研究期间疗效和安全性的差异。方法应用循证医学方法对符合标准的19项研究进行分析，评价齐拉西酮与奥氮平治疗精神分裂症过程中有效率、治愈率、治疗后量表评分及不良反应等的差异。结果齐拉西酮与奥氮平治疗精神分裂症的有效率、治愈率和治疗后量表评分均无统计学差异（均P＞0.05）；不良反应齐拉西酮组多见失眠、锥体外系反应、心电图异常，奥氮平组多见嗜睡、体重增加、食欲增加、血糖增加，两组比较均有统计学差异（均P＜0.05）。结论齐拉西酮和奥氮平均是治疗精神分裂症的合适药物，治疗效果类似，但是其不良反应存在统计学差异。
目的評價齊拉西酮與奧氮平治療精神分裂癥對照研究期間療效和安全性的差異。方法應用循證醫學方法對符閤標準的19項研究進行分析，評價齊拉西酮與奧氮平治療精神分裂癥過程中有效率、治愈率、治療後量錶評分及不良反應等的差異。結果齊拉西酮與奧氮平治療精神分裂癥的有效率、治愈率和治療後量錶評分均無統計學差異（均P＞0.05）；不良反應齊拉西酮組多見失眠、錐體外繫反應、心電圖異常，奧氮平組多見嗜睡、體重增加、食欲增加、血糖增加，兩組比較均有統計學差異（均P＜0.05）。結論齊拉西酮和奧氮平均是治療精神分裂癥的閤適藥物，治療效果類似，但是其不良反應存在統計學差異。
목적평개제랍서동여오담평치료정신분렬증대조연구기간료효화안전성적차이。방법응용순증의학방법대부합표준적19항연구진행분석，평개제랍서동여오담평치료정신분렬증과정중유효솔、치유솔、치료후량표평분급불량반응등적차이。결과제랍서동여오담평치료정신분렬증적유효솔、치유솔화치료후량표평분균무통계학차이（균P＞0.05）；불량반응제랍서동조다견실면、추체외계반응、심전도이상，오담평조다견기수、체중증가、식욕증가、혈당증가，량조비교균유통계학차이（균P＜0.05）。결론제랍서동화오담평균시치료정신분렬증적합괄약물，치료효과유사，단시기불량반응존재통계학차이。
Objective To compare the efficacy and safety of ziprasidone with olanzapine in treatment of schizophrenia. Methods Nineteen studies were included and analyzed. The differences in efficiency, cure rate, scale score and adverse re-actions for treatment of schizophrenia between ziprasidone and olanzapine were evaluated. Results There were no differ-ences in efficiency, cure rate, scale score for treatment of schizophrenia between ziprasidone and olanzapine. The adverse re-actions of ziprasidone were mainly insomnia, extrapyramidal symptoms, abnormal electrocardiogram; and those of olanzapine were mainly lethargy, weight gain, increased appetite, increased blood sugar; the differences were statistical y significant. Conclusion Ziprasidone and olanzapine both are effective drugs for schizophrenia with a similar efficacy and different adverse reactions.
