实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2014年
5期
535-537
,共3页
宫颈癌%新辅助化疗%术前放疗%复发%转移
宮頸癌%新輔助化療%術前放療%複髮%轉移
궁경암%신보조화료%술전방료%복발%전이
Cervical cancer%Neoadjuvant chemotherapy%Preoperative radiotherapy%Recurrence%Mmetastasis
目的:探讨新辅助化疗与术前放疗对宫颈癌手术治疗效果的影响。方法选择宫颈癌患者作为研究对象,随机分为给予新辅助化疗联合放疗的观察组以及仅给予新辅助化疗的对照组,观察治疗后肿瘤分期、肿瘤内分泌指标、手术相关指标及远期预后、生活质量及不良反应。结果观察组的肿瘤分期好于对照组,VEGF含量(68.2±10.5)以及术后部复发(8.89%)、远处转移(6.67%)、恶心呕吐(11.11%)、神经毒性(22.22%)、肝功能损害(11.11%)、肾功能损害(13.33%)均低于对照组;sVEGFR-1含量(198.3±28.1)、手术时间(81.3±13.2)min、术中出血量(46.2±8.9)ml、术后引流量(31.9±7.4)ml、5年存活率(93.33%)、躯体功能(73.45±8.24)、心理功能(58.42±6.28)、社会功能(56.84±6.14)、总体生存质量(82.08±6.65)均高于对照组(P<0.05)。结论新辅助化疗联合术前放疗能够有效地降低肿瘤分期、减弱肿瘤浸润能力、防止术后复发和转移,提高患者生活质量,具有积极的临床价值。
目的:探討新輔助化療與術前放療對宮頸癌手術治療效果的影響。方法選擇宮頸癌患者作為研究對象,隨機分為給予新輔助化療聯閤放療的觀察組以及僅給予新輔助化療的對照組,觀察治療後腫瘤分期、腫瘤內分泌指標、手術相關指標及遠期預後、生活質量及不良反應。結果觀察組的腫瘤分期好于對照組,VEGF含量(68.2±10.5)以及術後部複髮(8.89%)、遠處轉移(6.67%)、噁心嘔吐(11.11%)、神經毒性(22.22%)、肝功能損害(11.11%)、腎功能損害(13.33%)均低于對照組;sVEGFR-1含量(198.3±28.1)、手術時間(81.3±13.2)min、術中齣血量(46.2±8.9)ml、術後引流量(31.9±7.4)ml、5年存活率(93.33%)、軀體功能(73.45±8.24)、心理功能(58.42±6.28)、社會功能(56.84±6.14)、總體生存質量(82.08±6.65)均高于對照組(P<0.05)。結論新輔助化療聯閤術前放療能夠有效地降低腫瘤分期、減弱腫瘤浸潤能力、防止術後複髮和轉移,提高患者生活質量,具有積極的臨床價值。
목적:탐토신보조화료여술전방료대궁경암수술치료효과적영향。방법선택궁경암환자작위연구대상,수궤분위급여신보조화료연합방료적관찰조이급부급여신보조화료적대조조,관찰치료후종류분기、종류내분비지표、수술상관지표급원기예후、생활질량급불량반응。결과관찰조적종류분기호우대조조,VEGF함량(68.2±10.5)이급술후부복발(8.89%)、원처전이(6.67%)、악심구토(11.11%)、신경독성(22.22%)、간공능손해(11.11%)、신공능손해(13.33%)균저우대조조;sVEGFR-1함량(198.3±28.1)、수술시간(81.3±13.2)min、술중출혈량(46.2±8.9)ml、술후인류량(31.9±7.4)ml、5년존활솔(93.33%)、구체공능(73.45±8.24)、심리공능(58.42±6.28)、사회공능(56.84±6.14)、총체생존질량(82.08±6.65)균고우대조조(P<0.05)。결론신보조화료연합술전방료능구유효지강저종류분기、감약종류침윤능력、방지술후복발화전이,제고환자생활질량,구유적겁적림상개치。
Objective To study the effect of neoadjuvant chemotherapy and preoperative radiotherapy for cervical canc -er.Methods Cervical cancer patients were enrolled and randomly divided into observation group given neoadjuvant chemothera -py combined with radiotherapy ,and the control group only given neoadjuvant chemotherapy .Tumor stage ,endocrine indexes ,oper-ation related indexes , long-term prognosis , quality of life and adverse reactions were observed after treatment .Results Tumor stage of the observation group was better than that of the control group ,VEGF ratio(68.2 ±10.5),local recurrence(8.89%), distant metastasis(6.67%),nausea and vomiting (11.11%),nerve toxicity (22.22%),liver function impairment (11.11%), and renal function impairment (13.33%) in the observation group were lower than those of the control group ,sVEGFR-1 ratio (198.3 ±28.1),operation time(81.3 ±13.2)min,intraoperative bleeding volume (46.2 ±8.9)ml,postoperative drainage vol-ume (31.9 ±7.4)ml and 5-year survival rate (93.33%),physical function (73.45 ±8.24),psychological function (58.42 ± 6.28),social function (56.84 ±6.14),and overall quality of life (82.08 ±6.65)in the observation group were higher than those of the control group(P<0.05).Conclusion Neoadjuvant chemotherapy combined with preoperative radiotherapy has positive clinical value for cervical cancer,it can effectively reduce tumor stage,weaken tumor invasion,prevent postoperative recurrence and metastasis ,and improve quality of life .