CAJ | 학술논문

代谢组学是近年发展起来的对某一生物或细胞所有低分子质量代谢产物进行定性和定量分析的新学科。论文对代谢组学的概况及研究方法进行了介绍，并对代谢组学分析技术在生殖领域中的最新应用进行了综述。利用代谢组学分析技术对卵泡液、精液及体外受精胚胎的培养基进行研究，发现多种可能与卵母细胞，精子的活力及体外受精胚胎发育潜能相关的生物标记物。在对精液的代谢组学研究中，还发现了可能用于生殖器官癌症诊断的生物标记物。代谢物易获得且对机体损伤小，因此利用代谢组学分析技术寻找与疾病相关的生物标记物，再通过检测机体生物标记物的变化，判断机体的生理状态已成为代谢组学的研究趋势之一。
대사조학시근년발전기래적대모일생물혹세포소유저분자질량대사산물진행정성화정량분석적신학과。논문대대사조학적개황급연구방법진행료개소，병대대사조학분석기술재생식영역중적최신응용진행료종술。이용대사조학분석기술대란포액、정액급체외수정배태적배양기진행연구，발현다충가능여란모세포，정자적활력급체외수정배태발육잠능상관적생물표기물。재대정액적대사조학연구중，환발현료가능용우생식기관암증진단적생물표기물。대사물역획득차대궤체손상소，인차이용대사조학분석기술심조여질병상관적생물표기물，재통과검측궤체생물표기물적변화，판단궤체적생리상태이성위대사조학적연구추세지일。
Metabonomics is a newly developed subject used to qualitatively and quantitatively analyze all lowmolecular weight metabolites in an organism or cell in recent years.In this paper,the general situation andresearch methods of metabonomics were summarized,and applications of metabonomics analysis of the lat-est research progress in the field of reproduction were introduced.When the technique was adopted to studythe follicular fluid,semen and medium for in vitro embryo culture,several biomarkers possibly relatedwith the vitality of oocytes or sperms and the reproductive potential of embryos were found.In metabo-nomic study on semen,the possible biomarkers for genital cancer diagnosis were also found.The metaboliteis easy to obtain and little harmful to the body,so using metabonomic analysis techniques to find biomark-ers associated with disease,then judging the body's physiological state by detecting changes in the biomar-kers have become one of the trends of metabonomics study.