CAJ | 학술논문

哺乳动物的瘦素（leptin）主要由脂肪细胞合成和分泌，通过血液循环运输到全身，与靶细胞上的受体结合，启动一系列相关的信号转导，发挥广泛的生物学活性。瘦素的血管生成效应自从被发现以来一直被人们关注，现在已应用于各种与血管生成相关的领域中。瘦素可以促进血管内皮细胞的增殖，促进组织间血管的生成和肿瘤组织血管的生成。其他器官如胎盘和禽类的尿囊膜也可以分泌瘦素，调节胎盘或尿囊膜血管的生成，影响胚胎和鸡胚的发育。
포유동물적수소（leptin）주요유지방세포합성화분비，통과혈액순배운수도전신，여파세포상적수체결합，계동일계렬상관적신호전도，발휘엄범적생물학활성。수소적혈관생성효응자종피발현이래일직피인문관주，현재이응용우각충여혈관생성상관적영역중。수소가이촉진혈관내피세포적증식，촉진조직간혈관적생성화종류조직혈관적생성。기타기관여태반화금류적뇨낭막야가이분비수소，조절태반혹뇨낭막혈관적생성，영향배태화계배적발육。
Leptin is mainly synthesized and secreted by fat cells in mammals.Leptin is transported by blood and binds to leptin receptors on target cells to play a wide range of biological activity through initiating a series of related signaling pathways.Leptin is used in various fields since the angiogenic effects of leptin have been found,such as leptin promotes vascular endothelial cell proliferation,and promote angiogenesis of tissues and tumor and so on.Furthermore some organs such as placenta or poultry chorioallantoic mem-brane secrete leptin to regulate its angiogenesis,and affect the development of the embryo or chick embry-os.