CAJ | 학술논문

目的：探讨早期宫颈癌新辅助化疗的疗效和安全性。方法：选择Ib1期至IIb期宫颈癌39例，采用DBM方案动脉灌注化疗1-2个疗程后，行腹腔镜下广泛性子宫切除术及盆腔淋巴结清扫术；观察化疗前后癌灶的变化、化疗副反应及术后病理结果等指标。结果：全部病例化疗后宫颈局部肿瘤直径均不同程度缩小，化疗有效率100％；3例IIb期宫旁病灶改善不满意直接行放疗，其余36例行腹腔镜下宫颈癌根治术；手术成功率100％；有12例（12/36）术后病理结果未发现癌灶。主要毒副反应为消化道症状及I-II度白细胞减少，用药后可缓解。结论：宫颈癌新辅助化疗近期疗效好，副反应轻。
목적：탐토조기궁경암신보조화료적료효화안전성。방법：선택Ib1기지IIb기궁경암39례，채용DBM방안동맥관주화료1-2개료정후，행복강경하엄범성자궁절제술급분강림파결청소술；관찰화료전후암조적변화、화료부반응급술후병리결과등지표。결과：전부병례화료후궁경국부종류직경균불동정도축소，화료유효솔100％；3례IIb기궁방병조개선불만의직접행방료，기여36례행복강경하궁경암근치술；수술성공솔100％；유12례（12/36）술후병리결과미발현암조。주요독부반응위소화도증상급I-II도백세포감소，용약후가완해。결론：궁경암신보조화료근기료효호，부반응경。
Objective:To evaluate the response and security to neoadjuvant chemotherapy ( NACT) in patients of Ib1-IIb cervical cancer .Method:A retrospective study were made on 39 cervical cancer patients ( FIGO stage Ib1-IIb) underwent this DBM therapy by arterial infusion chemotherapy for 1 or 2 courses and followed by radical hysterectomy .The observation indexes included the change of the local lesion , side effect and pathological outcomes after the surgery .Result: All the patients indicated reduction of the lesions .the effective rate was 100%.Except 3 patients in IIb stage took radiotherapy , the rest take laparoscopic radical operation.The success rate of operation was 100%.There’re 12 (12/36) pathological reports showed that no cancer residue were detected .The main side effects were symptom of digestive tract like nausea and vomiting and I-II degree leucocytopenia .All these symptoms could be remittent after the symptomatic treatment .Con-clusion:Neoadjuvant chemotherapy ( NACT) is effective in short-term efficacy and the side effect is tolera-ble.