河北医学
河北醫學
하북의학
HEBEI MEDICINE
2014年
4期
543-546
,共4页
吴苏冬%朱奇%康静波%聂青
吳囌鼕%硃奇%康靜波%聶青
오소동%주기%강정파%섭청
原发性肝癌%动脉栓塞介入治疗%三维适形放疗%临床疗效
原髮性肝癌%動脈栓塞介入治療%三維適形放療%臨床療效
원발성간암%동맥전새개입치료%삼유괄형방료%림상료효
Primary hepatocellular carcinoma%Transcatheter arterial chemoembolization%Three-dimensional conformal radiotherapy%Clinical effects
目的：本研究通过观察动脉栓塞化疗（ transcatheter arterial chemoembolization ， TACE ）结合三维适形放疗（three-dimensional conformal radiotherapy ，3D-CRT）对中晚期肝癌患者的临床效果，探讨提高肝癌患者生存质量的有效方法，为后续临床研究提供参考。方法：选取2006年5月至2008年7月我院收治的55例不适宜手术治疗的中晚期肝癌患者为研究对象，采用肝动脉栓塞介入治疗与三维适形放疗相结合的方法进行治疗。观察患者治疗后的临床疗效、毒副反应发生情况等。结果：本组患者治疗的总有效率为74．6％；毒副反应主要表现为骨髓抑制、恶心呕吐及肝功能损害等，经对症治疗获得缓解；随访发现患者肿瘤局部复发率为22．7％，远处转移率为13．2％，5年生存率为68．8％，明显高于治疗前估值，差异具有统计学意义（ P＜0．05）。结论：在中晚期肝癌的临床治疗中，对患者实施放射治疗的同时选择合理的药物及给药方案进行化疗具有明显的近期疗效，患者的毒副反应可耐受，且治疗后的生存率较高，值得临床推广应用。
目的：本研究通過觀察動脈栓塞化療（ transcatheter arterial chemoembolization ， TACE ）結閤三維適形放療（three-dimensional conformal radiotherapy ，3D-CRT）對中晚期肝癌患者的臨床效果，探討提高肝癌患者生存質量的有效方法，為後續臨床研究提供參攷。方法：選取2006年5月至2008年7月我院收治的55例不適宜手術治療的中晚期肝癌患者為研究對象，採用肝動脈栓塞介入治療與三維適形放療相結閤的方法進行治療。觀察患者治療後的臨床療效、毒副反應髮生情況等。結果：本組患者治療的總有效率為74．6％；毒副反應主要錶現為骨髓抑製、噁心嘔吐及肝功能損害等，經對癥治療穫得緩解；隨訪髮現患者腫瘤跼部複髮率為22．7％，遠處轉移率為13．2％，5年生存率為68．8％，明顯高于治療前估值，差異具有統計學意義（ P＜0．05）。結論：在中晚期肝癌的臨床治療中，對患者實施放射治療的同時選擇閤理的藥物及給藥方案進行化療具有明顯的近期療效，患者的毒副反應可耐受，且治療後的生存率較高，值得臨床推廣應用。
목적：본연구통과관찰동맥전새화료（ transcatheter arterial chemoembolization ， TACE ）결합삼유괄형방료（three-dimensional conformal radiotherapy ，3D-CRT）대중만기간암환자적림상효과，탐토제고간암환자생존질량적유효방법，위후속림상연구제공삼고。방법：선취2006년5월지2008년7월아원수치적55례불괄의수술치료적중만기간암환자위연구대상，채용간동맥전새개입치료여삼유괄형방료상결합적방법진행치료。관찰환자치료후적림상료효、독부반응발생정황등。결과：본조환자치료적총유효솔위74．6％；독부반응주요표현위골수억제、악심구토급간공능손해등，경대증치료획득완해；수방발현환자종류국부복발솔위22．7％，원처전이솔위13．2％，5년생존솔위68．8％，명현고우치료전고치，차이구유통계학의의（ P＜0．05）。결론：재중만기간암적림상치료중，대환자실시방사치료적동시선택합리적약물급급약방안진행화료구유명현적근기료효，환자적독부반응가내수，차치료후적생존솔교고，치득림상추엄응용。
Objective:To discuss the best method of liver cancer by observing the clinical efficacy of the TACE combined with 3D-CRT on the treatment of metaphase and advanced hepatocellular carcinoma , to provide a reference for subsequent research .Methods:55 cases with metaphase and advanced liver cancer who were less proper to take the resections in our hospital from May 2006 to July 2008 were selected .The pa-tients were treated by the TACE combined with 3D-CRT.Then the clinical effects, the incidence of adverse reactions and the situation of follow-ups were observed and analyzed .Results:The total effective rate of pa-tients was 74.6%; The main adverse reactions were the myelosuppression , nausea and vomiting , and liver damage .of patients after the treatment and got the remission by symptomatic methods .It was found by follow-ups that the rate of recurrence was 22.7%, the rate of metastasis was 13.2%, the rate of five-years’ sur-vival was 68.8%which was higher than the prediction before the treatment with statistically significant differ-ence(P<0.05).Conclusion:It suggests that the methods of TACE combined with 3D-CRT should be well promoted to the clinical treatment for patients with the metaphase or advanced liver cancer when applied with the reasonable medication and dosage regimen , because the clinical effects and the survival rate of patients are obviously higher , and the adverse reactions might be accepted .
