CAJ | 학술논문

将撞击流技术与超临界流体膨胀减压过程结合，以利福平为模型材料，考察该技术用于脂溶性药物超细微粒制备的可行性，系统分析了混合器的压力和温度、溶液浓度、进液速率、析出器的温度及撞击距离对微粒粒径及粒径分布的影响。结果表明，与超临界流体膨胀减压过程相比，超临界流体膨胀减压-撞击流技术可制备出形态更好的利福平球形微粒，微粒粒径更小、分布更均匀。采用撞击流技术后，减弱了超临界流体膨胀减压过程参数(如溶液浓度、进液速率等)对微粒的不利因素，可在较大的操作范围内制得粒径分布均匀的微粒；同时强化了液滴和热气体之间的传质和传热，微粒干燥效果得到了明显改善，在低于超临界流体膨胀减压过程适宜析出器温度10℃时，仍能得到分散性较好的微粒，有效降低了能耗。
장당격류기술여초림계류체팽창감압과정결합，이리복평위모형재료，고찰해기술용우지용성약물초세미립제비적가행성，계통분석료혼합기적압력화온도、용액농도、진액속솔、석출기적온도급당격거리대미립립경급립경분포적영향。결과표명，여초림계류체팽창감압과정상비，초림계류체팽창감압-당격류기술가제비출형태경호적리복평구형미립，미립립경경소、분포경균균。채용당격류기술후，감약료초림계류체팽창감압과정삼수(여용액농도、진액속솔등)대미립적불리인소，가재교대적조작범위내제득립경분포균균적미립；동시강화료액적화열기체지간적전질화전열，미립간조효과득도료명현개선，재저우초림계류체팽창감압과정괄의석출기온도10℃시，잉능득도분산성교호적미립，유효강저료능모。
The supercritical fluid expansion depressurization process was combined with the impinging stream technology.The feasibility of this technology to prepare lipid-soluble drug microparticles was investigated with rifampicin as model material.The influences of the operation parameters,including the pressure and tempera-ture in the mixing vessel,the solution concentration,the solution feed rate and the temperature of the precipita-tor,on the particle diameter and diameter distribution were studied in detail.Results of this study indicate that,in comparison with the supercritical fluid expansion depressurization process,the rifampicin microparticles with more well-defined morphology,smaller particle diameter and narrower diamater distribution were prepared by the supercritical fluid expansion depression-impinging stream technology.When the impinging stream tech-nology was applied the unfavorable factors of the supercritical fluid expansion depressization to affect the micro-particle character were weakened.The microparticles with well distribution can be obtained in a wider operation range.In addition,the heat and mass transfer between liquid droplets and heat gas were enhanced and the dr-ying effect of microparticle was improved obviously.The well dispersion microparticles were obtained at the 10 ℃ lower than the optimal precipitator temperature of the supercritical fluid expansion depressuzation.The energy consumption was reduced significantly.