CAJ | 학술논문

采用模板聚合法以甲基丙烯酸(MA )、甲基丙烯酰氧乙基磷酰胆碱(MP C )为单体，以过硫酸钾为引发剂和壳聚糖进行聚合，制备具有仿细胞外层膜结构壳聚糖纳米颗粒。用动态光散射仪(DLS)、透射电镜(TEM)和zeta电位对纳米颗粒的粒径、zeta 电位进行表征，并通过体外阿霉素控释实验对该纳米颗粒的控释性能进行研究。该仿细胞外层膜结构壳聚糖纳米颗粒将在基因治疗、药物控释等领域具有巨大的应用前景。该研究对于探索仿细胞外层膜结构纳米颗粒的控释性能具有重要的学术意义。
채용모판취합법이갑기병희산(MA )、갑기병희선양을기린선담감(MP C )위단체，이과류산갑위인발제화각취당진행취합，제비구유방세포외층막결구각취당납미과립。용동태광산사의(DLS)、투사전경(TEM)화zeta전위대납미과립적립경、zeta 전위진행표정，병통과체외아매소공석실험대해납미과립적공석성능진행연구。해방세포외층막결구각취당납미과립장재기인치료、약물공석등영역구유거대적응용전경。해연구대우탐색방세포외층막결구납미과립적공석성능구유중요적학술의의。
The cell outer membrane mimetic structures of nanoparticles were prepared using methacrylic acid (MA),2-methacryloyloxyethyl phosphorylcholine (MPC)as monomer,potassium persulfate (KPS)and chi-tosan by template polymerization.The size distribution and structure properties of nanoparticles were character-ized by transmission electron microscopy (TEM),dynamic light scattering (DLS)and zeta potential.The drug release properties of nanoparticles were estimated by doxorubicin in vitro release experiment.The cell outer membrane mimetic structures of nanoparticles might have potential applications in the fields of gene therapy and drug delivery.The controlled release properties had been an important academic significance on the study of outer cell membrane structures of nanoparticles.