CAJ | 학술논문

支气管哮喘常表现为不同的炎症表型，特异性生物标志物是不同炎性致病机制下的特定产物，它可以反映当前哮喘炎症浸润程度。通过分析嗜酸性粒细胞型、中性粒细胞型、白三烯型跟其他类型炎症表型哮喘相关的特异性生物标志物的水平，可以鉴别不同的哮喘表型，有助于进一步了解哮喘患者炎性细胞浸润程度和特点，预测哮喘恶化，进一步指导哮喘治疗和管理。
지기관효천상표현위불동적염증표형，특이성생물표지물시불동염성치병궤제하적특정산물，타가이반영당전효천염증침윤정도。통과분석기산성립세포형、중성립세포형、백삼희형근기타류형염증표형효천상관적특이성생물표지물적수평，가이감별불동적효천표형，유조우진일보료해효천환자염성세포침윤정도화특점，예측효천악화，진일보지도효천치료화관리。
Different inflammatory phenotypes are commonly manifested in asthma. Specific biomarkers are the products of diverse inflammatory pathogenic mechanism. Through the analysis of different specific biomarkers related to five major phenotypes such as eosinophilic phenotype, neutrophilic phenotype, leukotriene phenotype and mixed phenotype, it is available to discriminate diverse inflammatory phenotypes. Moreover, it renders it liable to obtain a better understanding of the extent of current inflammation and the possibility of exacerbation, thus contributing to a better therapy and management of asthma.