中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
5期
699-704
,共6页
马松峰%曹会%郑峰%乔峻%张国明
馬鬆峰%曹會%鄭峰%喬峻%張國明
마송봉%조회%정봉%교준%장국명
实验动物%组织构建%膜生物材料%瓣膜手术%冠状动脉旁路移植术%危险因素%二尖瓣返流%心脏瓣膜病
實驗動物%組織構建%膜生物材料%瓣膜手術%冠狀動脈徬路移植術%危險因素%二尖瓣返流%心髒瓣膜病
실험동물%조직구건%막생물재료%판막수술%관상동맥방로이식술%위험인소%이첨판반류%심장판막병
biocompatible materials%heart valves%coronary artery bypass,off-pump%mitral valve
背景:心脏瓣膜置换或成形同期行冠状动脉旁路移植手术的选择已成为目前治疗冠状动脉粥样化性心脏病合并心脏瓣膜病的发展趋势。<br> 目的:回顾性总结51例心脏瓣膜替换或成形同时行冠状动脉旁路移植手术的经验。<br> 方法:回顾性分析同期施行心脏瓣膜置换或成形及冠状动脉旁路移植患者51例临床资料,共移植旁路血管109支,同时行主动脉瓣置换10例,二尖瓣置换14例,二尖瓣置换联合三尖瓣成形8例,主动脉瓣联合二尖瓣双瓣置换4例,主动脉瓣、二尖瓣双瓣联合三尖瓣成形3例,二尖瓣成形7例,二尖瓣成形联合三尖瓣成形5例。<br> 结果与结论:置换生物瓣膜者9例,机械瓣膜者31例,二尖瓣成形11例,三尖瓣成形16例;共移植旁路血管109支,冠状动脉旁路移植平均搭桥(1.92±0.73)支;术后30 d内死亡4例。47例顺利出院,其中2例失访,45例随访3-48个月,1例半年后脑梗死,1例于术后1年多死于心脏功能不全,存活的43例心功能改善明显,均可进行一般的生活与活动。综合分析得出彻底解除瓣膜病变,充分保障心肌再血管化,保护心肌,尽量缩短主动脉阻断时间是手术成功的关键因素。
揹景:心髒瓣膜置換或成形同期行冠狀動脈徬路移植手術的選擇已成為目前治療冠狀動脈粥樣化性心髒病閤併心髒瓣膜病的髮展趨勢。<br> 目的:迴顧性總結51例心髒瓣膜替換或成形同時行冠狀動脈徬路移植手術的經驗。<br> 方法:迴顧性分析同期施行心髒瓣膜置換或成形及冠狀動脈徬路移植患者51例臨床資料,共移植徬路血管109支,同時行主動脈瓣置換10例,二尖瓣置換14例,二尖瓣置換聯閤三尖瓣成形8例,主動脈瓣聯閤二尖瓣雙瓣置換4例,主動脈瓣、二尖瓣雙瓣聯閤三尖瓣成形3例,二尖瓣成形7例,二尖瓣成形聯閤三尖瓣成形5例。<br> 結果與結論:置換生物瓣膜者9例,機械瓣膜者31例,二尖瓣成形11例,三尖瓣成形16例;共移植徬路血管109支,冠狀動脈徬路移植平均搭橋(1.92±0.73)支;術後30 d內死亡4例。47例順利齣院,其中2例失訪,45例隨訪3-48箇月,1例半年後腦梗死,1例于術後1年多死于心髒功能不全,存活的43例心功能改善明顯,均可進行一般的生活與活動。綜閤分析得齣徹底解除瓣膜病變,充分保障心肌再血管化,保護心肌,儘量縮短主動脈阻斷時間是手術成功的關鍵因素。
배경:심장판막치환혹성형동기행관상동맥방로이식수술적선택이성위목전치료관상동맥죽양화성심장병합병심장판막병적발전추세。<br> 목적:회고성총결51례심장판막체환혹성형동시행관상동맥방로이식수술적경험。<br> 방법:회고성분석동기시행심장판막치환혹성형급관상동맥방로이식환자51례림상자료,공이식방로혈관109지,동시행주동맥판치환10례,이첨판치환14례,이첨판치환연합삼첨판성형8례,주동맥판연합이첨판쌍판치환4례,주동맥판、이첨판쌍판연합삼첨판성형3례,이첨판성형7례,이첨판성형연합삼첨판성형5례。<br> 결과여결론:치환생물판막자9례,궤계판막자31례,이첨판성형11례,삼첨판성형16례;공이식방로혈관109지,관상동맥방로이식평균탑교(1.92±0.73)지;술후30 d내사망4례。47례순리출원,기중2례실방,45례수방3-48개월,1례반년후뇌경사,1례우술후1년다사우심장공능불전,존활적43례심공능개선명현,균가진행일반적생활여활동。종합분석득출철저해제판막병변,충분보장심기재혈관화,보호심기,진량축단주동맥조단시간시수술성공적관건인소。
BACKGROUND:Heart valve surgery combined with coronary artery bypass grafting has been gradual y used for treatment of coronary heart disease combined with cardiac valve disease. <br> OBJECTIVE:To retrospectively summarize the experience of combined coronary artery bypass grafting and valvular procedure. <br> METHODS:Total y 51 patients who underwent combined heart valve surgery and coronary artery bypass grafting were retrospectively analyzed, including 10 cases with aortic valve replacement, 14 cases with mitral valve replacement, eight cases with mitral valve replacement combined with tricuspid annuloplasty, four cases with aortic valve and mitral valve replacement, three cases with aortic valve and mitral valve replacement combined with tricuspid annuloplasty, seven cases with mitral valvuloplasty, and five cases with mitral valvuloplasty combined with tricuspid annuloplasty. <br> RESULTS AND CONCLUSION:Biovalve replacement was performed in nine patients, mechanical valves replacement in 31 cases, mitral valvuloplasty in 11 cases and tricuspid annuloplasty in 16 cases. There were total y 109 bypass graft vessels, and the average number of coronary artery bypass grafts was (1.92±0.73) branches. Four cases died within 30 days postoperatively, and 47 patients were successful y discharged from the hospital. Forty-five of 47 discharging patients were fol owed for 3-48 months. One case died of cerebral infarction within 6 months postoperatively, and another case died of cardiac dysfunction over 1 year after operation. The heart function of 45 survival patients was significantly improved. The comprehensive analysis showed that improving the heart function preoperatively, strengthening myocardial protection, shortening operation and myocardial ischemia time, and complete revascularization are the key factors for successful operation.