CAJ | 학술논문

目的：探讨肝硬化失代偿期合并低钠血症患者补充钠盐治疗的临床疗效。方法选取2010年3月至2012年6月解放军302医院收治的82例肝硬化合并低钠血症患者作为研究对象，根据血钠浓度将所选患者分为轻、中、重3组，分别为36、29、17例，对不同组别采用不同补钠治疗，并比较各组的治疗效果。结果3组患者采用补钠治疗后的血钠浓度相比于补充钠盐之前均明显上升，治疗前后比较差异有统计学意义（P＜0．05）；轻度低钠血症组补钠治疗后显效31例，显效率为86．11％；中度低钠血症组显效22例，显效率为75．86％；重度低钠血症组显效4例，显效率为23．53％；轻度低钠血症组显效率最高，中度低钠血症组显效率次之，重度低钠血症组显效率最低。轻度低钠血症组与中度低钠血症组显效率差异无统计学意义（P＞0．05），重度低钠血症组显效率与轻度低钠血症组及中度低钠血症组比较差异有统计学意义（P＜0．05）。结论肝硬化失代偿期合并轻中度低钠血症患者补钠能有效纠正，但重度低钠血症患者应用补充高张钠的方法疗效仍不理想，提示对于低钠血症的早期发现、及时干预可以改善预后。
목적：탐토간경화실대상기합병저납혈증환자보충납염치료적림상료효。방법선취2010년3월지2012년6월해방군302의원수치적82례간경화합병저납혈증환자작위연구대상，근거혈납농도장소선환자분위경、중、중3조，분별위36、29、17례，대불동조별채용불동보납치료，병비교각조적치료효과。결과3조환자채용보납치료후적혈납농도상비우보충납염지전균명현상승，치료전후비교차이유통계학의의（P＜0．05）；경도저납혈증조보납치료후현효31례，현효솔위86．11％；중도저납혈증조현효22례，현효솔위75．86％；중도저납혈증조현효4례，현효솔위23．53％；경도저납혈증조현효솔최고，중도저납혈증조현효솔차지，중도저납혈증조현효솔최저。경도저납혈증조여중도저납혈증조현효솔차이무통계학의의（P＞0．05），중도저납혈증조현효솔여경도저납혈증조급중도저납혈증조비교차이유통계학의의（P＜0．05）。결론간경화실대상기합병경중도저납혈증환자보납능유효규정，단중도저납혈증환자응용보충고장납적방법료효잉불이상，제시대우저납혈증적조기발현、급시간예가이개선예후。
Objective Discussion on the clinical efficacy of sodium treatment on patients with cirrhosis in the liver decompensation period complicated with hyponatremia .Methods Eighty two cases of cirrhosis with hyponatre-mia from 2010 March to 2012 June in our hospital were chose to be subjects ,then all the cases were divided into the light group ,the medium group and the severe group according to the serum sodium concentration ,the three groups included cases respectively 36 ,29 ,17 ,all the cases were gave an appropriate supplement of sodium .Results The ser-um sodium concentration of the patients in three groups were significantly increased compared to that before sodium treatment ,there was significant difference between the serum sodium concentration before and after treatment (P<0 .05) ,31cases in the light group were improved markedly after treatment with the efficiency rate 86 .11% ,22 cases in the mild group were improved markedly after treatment with the efficiency rate 75 .86% ,4 cases in the severe group were improved markedly after treatment 25 .53% ,The more serious the hyponatremia ,the lower efficiency of treatment show ,there was no significant difference in efficiency between the light group and the medium group (P>0 .05) ,severe hyponatremia group had significant differences with other groups in the efficiency (P<0 .05) .Conclu-sion Patients with cirrhosis in the liver decompensation period with mild to moderate hyponatremia can be effective-ly correct ,but for severe hyponatremia patients complement high sodium method is not ideal ,which implies for hy-ponatremia patients ,early detection ,timely intervention can improve the prognosis .