CAJ | 학술논문

目的：分析血清β2-微球蛋白（β2-MG）在妊娠高血压综合征（PIH）早期肾功能诊断中的临床意义。方法选择兰州军区临潼疗养院2011年1月至2013年6月确诊的PIH患者90例设为试验组，其中轻度PIH组26例，中度PIH组33例，重度PIH组31例。另选择妊娠26～41周并排除其他内科及产科合并症的健康体检孕妇76例为正常组。研究对象均采用免疫透射比浊法检测β2-M G水平，同时检测常规肾功能血清学指标：尿素（U rea ）、尿酸（UA）和肌酐（Cr）水平，并对检测结果进行比较分析。结果轻度PIH组血清β2-MG高于正常组，差异有统计学意义（P＜0．05），血清Urea、UA和Cr高于正常组，但差异无统计学意义（P＞0．05）；中度PIH组血清β2-MG、U-rea高于正常组，差异有统计学意义（P＜0．01），血清 UA、Cr高于正常组，但差异无统计学意义（P＞0．05）；重度PIH组血清β2-MG、Urea、UA和Cr水平明显高于正常组，差异有统计学意义（P＜0．01）。PIH组内β2-MG、Urea、UA和Cr水平随病情程度进展呈递增性升高。结论血清β2-MG水平可作为评估PIH患者早期肾功能损伤的常规生化指标，其水平变化能为PIH的临床早期诊断、病情监测和预后提供一定的参考价值。
목적：분석혈청β2-미구단백（β2-MG）재임신고혈압종합정（PIH）조기신공능진단중적림상의의。방법선택란주군구림동요양원2011년1월지2013년6월학진적PIH환자90례설위시험조，기중경도PIH조26례，중도PIH조33례，중도PIH조31례。령선택임신26～41주병배제기타내과급산과합병증적건강체검잉부76례위정상조。연구대상균채용면역투사비탁법검측β2-M G수평，동시검측상규신공능혈청학지표：뇨소（U rea ）、뇨산（UA）화기항（Cr）수평，병대검측결과진행비교분석。결과경도PIH조혈청β2-MG고우정상조，차이유통계학의의（P＜0．05），혈청Urea、UA화Cr고우정상조，단차이무통계학의의（P＞0．05）；중도PIH조혈청β2-MG、U-rea고우정상조，차이유통계학의의（P＜0．01），혈청 UA、Cr고우정상조，단차이무통계학의의（P＞0．05）；중도PIH조혈청β2-MG、Urea、UA화Cr수평명현고우정상조，차이유통계학의의（P＜0．01）。PIH조내β2-MG、Urea、UA화Cr수평수병정정도진전정체증성승고。결론혈청β2-MG수평가작위평고PIH환자조기신공능손상적상규생화지표，기수평변화능위PIH적림상조기진단、병정감측화예후제공일정적삼고개치。
Objective To analysis on the value of serum β2 microglobulin(β2-MG) in the diagnosis of early di-agnosis of renal function in patients with pregnancy induced hypertension syndrome (referred to as :PIH) .Methods Serum β2-MG level were tested by immune transmission turbidity assay in 90 cases patients with PIH included the mild goup 26 cases ,the moderate group 33 cases and the severe group 31cases .and 76 cases healthy persons ,serum Urea(Urea) ,uric acid(UA) and creatinine(Cr) levels were tested at the same time and a comparative analysis was did .Results The mild PIH group serum β2-MG、Urea were higher than in the normal group ,the difference has sta-tistical significance(P<0 .05) ,serum Urea ,UA and Cr was higher than those in the normal group ,no statistical sig-nificance(P>0 .05);moderate PIH group serum β2-MG was higher than that in the normal group ,the difference was statistically significant(P<0 .01) ,serum UA and Cr was higher than those in the normal group ,no statistical signifi-cance was found(P>0 .05);severe PIH group serum β2-MG ,Urea ,UA and Cr levels were higher than those in the normal group ,the difference was statistically significant(P<0 .01) .In the PIH groupβ2-MG ,Urea ,UA and Cr lev-els were increasing with the severity of the disease .Conclusion The serum β2-MG level can be used to evaluate con-ventional biochemical indexes in the diagnosis of renal damage in patients with PIH ,its concentration level changes can provide some valuable reference for PIH early clinical diagnosis ,disease monitoring and prognosis .