CAJ | 학술논문

目的：分析贵州地区8102例就诊妇女人乳头瘤病毒（H PV ）的感染情况、亚型分布特点。方法采用填写调查表方式，对受检妇女的一般情况、宫颈病变病理分级及 H PV 感染的高危因素进行调查；采用凯普核酸分子导流杂交基因芯片技术进行21种 HPV DNA亚型分析。结果8102例就诊妇女21种 HPV型别全部检出，阳性率为34．47％，高危型 HPV阳性率29．60％，低危型为5．20％，高危型检出率的前3位是 HPV16、52和58亚型，低危型以HPV11和6亚型为主。3040例宫颈炎患者中检出944例 HPV 阳性，阳性率为31．05％，高危型HPV阳性率26．64％，低危型HPV阳性率3．68％，高危型中检出率前6位的是 HPV16、52、58、33、18和31亚型，低危型以11和6亚型为主；433例宫颈上皮内瘤变（CIN）Ⅰ～Ⅲ患者共检出240例 HPV高危型阳性，阳性率为55．43％，检出率前6位是16、58、52、33、18和51亚型；249例宫颈癌患者共检出196例 H PV高危型阳性，阳性率78．71％，检出率前6位是16、58、18、52、33和31亚型；宫颈炎、CIN Ⅰ～Ⅲ和宫颈癌组均以单一型感染为主。受检者不同初次性生活年龄、伴侣个数、妊娠次数、生育次数的HPV感染率差异无统计学意义（P＞0．05）。结论贵州地区就诊妇女 H PV感染率较高，16、52、58和18亚型为较常见高危亚型，6和11亚型为较常见低危亚型。
목적：분석귀주지구8102례취진부녀인유두류병독（H PV ）적감염정황、아형분포특점。방법채용전사조사표방식，대수검부녀적일반정황、궁경병변병리분급급 H PV 감염적고위인소진행조사；채용개보핵산분자도류잡교기인심편기술진행21충 HPV DNA아형분석。결과8102례취진부녀21충 HPV형별전부검출，양성솔위34．47％，고위형 HPV양성솔29．60％，저위형위5．20％，고위형검출솔적전3위시 HPV16、52화58아형，저위형이HPV11화6아형위주。3040례궁경염환자중검출944례 HPV 양성，양성솔위31．05％，고위형HPV양성솔26．64％，저위형HPV양성솔3．68％，고위형중검출솔전6위적시 HPV16、52、58、33、18화31아형，저위형이11화6아형위주；433례궁경상피내류변（CIN）Ⅰ～Ⅲ환자공검출240례 HPV고위형양성，양성솔위55．43％，검출솔전6위시16、58、52、33、18화51아형；249례궁경암환자공검출196례 H PV고위형양성，양성솔78．71％，검출솔전6위시16、58、18、52、33화31아형；궁경염、CIN Ⅰ～Ⅲ화궁경암조균이단일형감염위주。수검자불동초차성생활년령、반려개수、임신차수、생육차수적HPV감염솔차이무통계학의의（P＞0．05）。결론귀주지구취진부녀 H PV감염솔교고，16、52、58화18아형위교상견고위아형，6화11아형위교상견저위아형。
Objective To analyze the prevalence of human papillomavirus(HPV) among 8 102 female patients in Guizhou .Methods General situation ,pathological grade of cervical lesions and high risk factors of HPV infection were investigated by using questionnaire .HPV genotypes were detected by using nucleic acid molecule flow -through hybridization and gene chip technology .Results A total of 21 genotypes of HPV were identified in 8 102 femal pa-tients ,with the positive rate of 34 .47% .The positive rates of high-risk HPV and low-risk HPV were was 29 .60%and 5 .20% .The top three common high-risk HPV ,ranged from high to low according to positive rate were HPV-16 , 52 ,58 ,and the main genotypes of low-risk HPV were HPV 6 and 11 .Among 2 040 cases with cervicitis ,249 cases were positive with HPV infection ,and the positive rate was 31 .05% ,including 26 .64% of high-risk HPV infection and 3 .68% of low-risk HPV infection .In patients with cervicitis ,the most common genotypes of high-risk HPV were HPV 16 ,52 and 58 ,and the most common genotypes of low-risk HPV were HPV 11 and 6 .Among 249 cases with cervical intraepithelial neoplasia(CINⅠ - Ⅲ) ,240 cases(55 .43% ) were positive with high-risk HPV infection ,and the most common genotypes were HPV 16 ,58 ,18 ,52 ,33 and 51 .Among 249 cases with cervical cancer ,196 cases (78 .71% ) were positive with high-risk HPV infection ,and the most common genotypes were HPV 16 ,58 ,18 ,52 ,33 and 31 .The main type of infection in patients with cervicitis ,CIN Ⅰ - Ⅲ or cervical cancer were single genotype in-fection .Positive rate of HPV were not correlated with the age of first sexual life ,number of sexual partners ,times of pregnancy and times of delivery(P>0 .05) .Conclusion The infection rate of HPV might be high in female patients of Guizhou region .The most common genotypes of HPV could be HPV 16 ,52 ,58 and 18 ,and the most common gen-otypes of HPV could HPV 6 and 11 .