CAJ | 학술논문

目的：探讨神经衰弱和抑郁症患者在事件相关电位（ERP ）P300的不同表现。方法收集2012年3月至2013年3月湛江中心人民医院35例神经衰弱患者和32例抑郁症患者以及35例健康成人进行ERP测定，采用日本光电诱发电位仪以听觉 Oddball刺激序列刺激，完成 P300测量。结果与健康对照组比较，神经衰弱组P300潜伏期延长；抑郁症组P300潜伏期延长，波幅降低，差异均具有统计学意义（ P＜0．05）。神经衰弱组与抑郁症组比较，抑郁组P300潜伏期延长及波幅降低明显，差异具有统计学意义（ P＜0．05）。结论抑郁症患者认知功能受损较神经衰弱患者更为显著，P300作为与认知相关的诱发电位，可为神经衰弱及抑郁症患者的诊断及鉴别诊断提供脑电生理方面的依据。
목적：탐토신경쇠약화억욱증환자재사건상관전위（ERP ）P300적불동표현。방법수집2012년3월지2013년3월담강중심인민의원35례신경쇠약환자화32례억욱증환자이급35례건강성인진행ERP측정，채용일본광전유발전위의이은각 Oddball자격서렬자격，완성 P300측량。결과여건강대조조비교，신경쇠약조P300잠복기연장；억욱증조P300잠복기연장，파폭강저，차이균구유통계학의의（ P＜0．05）。신경쇠약조여억욱증조비교，억욱조P300잠복기연장급파폭강저명현，차이구유통계학의의（ P＜0．05）。결론억욱증환자인지공능수손교신경쇠약환자경위현저，P300작위여인지상관적유발전위，가위신경쇠약급억욱증환자적진단급감별진단제공뇌전생리방면적의거。
Objective To investigate the changes of event-related potentials P300 in patients with neurasthenia and depression .Methods Event-related potentials P300 were recorded form 35 neurasthenia patients and 32 depres-sion patients ,compared with 35 healthy adults in control group by using Nihon Kohden instruments .Results Com-pared with the healthy adult in control group ,the latency of P300 was longer(P<0 .05)in the patients with neuras-thenia;the latency of P300 was longer and the amplitude of P300 was lower in the patients with depression (P<0 .05) .The latency of P300 in the patients with depression was longer than in the patients with neurasthenia ,the am-plitude of P300 in the patients with depression was lower than in the patients with neurasthenia (P<0 .05) .Conclu-sion Neurasthenia and depression are different in the features of P300 ,impaired cognitive function was even more serious in the patients with depression .P300 could provide an electrophysiology basis for the diagnosis and differenti-al diagnosis for neurasthenia and depression .