CAJ | 학술논문

目的：对系统性红斑狼疮（SLE）患者血清基质金属蛋白酶-9（MMP-9）的浓度变化进行系统评价。方法使用循证医学文献分析方法，从CBM、CNKI、维普科技期刊数据库及Pubmed文献数据库中检索有关SLE患者血清M M P-9浓度的文献，使用Rev M an5．0软件进行M eta分析。结果共有7篇文献入选，M eta分析结果显示SLE患者血清MMP-9浓度与健康对照组相比差异无统计学意义（P＞0．05）。结论血清MMP-9浓度不足以用作SLE协助诊断及疗效判断的指标。
목적：대계통성홍반랑창（SLE）환자혈청기질금속단백매-9（MMP-9）적농도변화진행계통평개。방법사용순증의학문헌분석방법，종CBM、CNKI、유보과기기간수거고급Pubmed문헌수거고중검색유관SLE환자혈청M M P-9농도적문헌，사용Rev M an5．0연건진행M eta분석。결과공유7편문헌입선，M eta분석결과현시SLE환자혈청MMP-9농도여건강대조조상비차이무통계학의의（P＞0．05）。결론혈청MMP-9농도불족이용작SLE협조진단급료효판단적지표。
Objective To evaluate systemically the change of serum MMP-9 concentration in patients with systemic lupus erythematosus (SLE ) .Methods By literature analysis based on evidence-based medicine ,articles a-bout serum concentration of MMP-9 in SLE patients were obtained from data bases of Pubmed ,CBM ,CNKI and VIP .Results A total of seven literatures were selected and no difference was found between serum concentration of MMP-9 in SLE patients and that of healthy controls .Conclusion Serum concentration of MMP-9 should not be used as index for diagnosis and therapy in SLE .