CAJ | 학술논문

小窝蛋白-1（Caveolin-1）是caveolae上的主要结构功能蛋白，通过它的脚手架区（CSD）与多个重要蛋白直接结合，形成信号通路的枢纽中心，在细胞增殖、迁移和分化，肿瘤的发生和转移等生理、病理过程中发挥重要作用。在正常生理条件下和结肠癌、肝癌、乳腺癌等肿瘤的早期，Caveolin-1-信号分子复合物负性调控各种信号通路。而在泌尿系肿瘤的各个时期和其他大多数肿瘤的晚期， Caveolin-1异常表达，激活各种生长信号的传导，促进肿瘤细胞生长、增殖和转移。Caveolin-1在肿瘤中表现出的双重效应与它调控的信号通路相关。本文将就Caveolin-1在肿瘤细胞中调控的信号通路做具体阐述。
소와단백-1（Caveolin-1）시caveolae상적주요결구공능단백，통과타적각수가구（CSD）여다개중요단백직접결합，형성신호통로적추뉴중심，재세포증식、천이화분화，종류적발생화전이등생리、병리과정중발휘중요작용。재정상생리조건하화결장암、간암、유선암등종류적조기，Caveolin-1-신호분자복합물부성조공각충신호통로。이재비뇨계종류적각개시기화기타대다수종류적만기， Caveolin-1이상표체，격활각충생장신호적전도，촉진종류세포생장、증식화전이。Caveolin-1재종류중표현출적쌍중효응여타조공적신호통로상관。본문장취Caveolin-1재종류세포중조공적신호통로주구체천술。
Caveolin-1 is the main structural and functional protein in the caveolae.A variety of important signal proteins combined with the scaffold area(CSD),forming the center of signalings and regulating.In cell proliferation,migration and differentiation,tumorigenesis and metastasis and other physiological,pathological processes play an important role.In normal physiological conditions and the early of colon cancer,liver cancer,breast cancer, Caveolin-1 inhibit these signalings proteins,whlie in each period of urinary tract tumors and the late of others tumors,the overexpression of Caveolin-1 promotes all sorts of growth signals and induces tumor cells growth,proliferation and metastasis.The double effect of Caveolin-1 in tumor is related to its signalings.This review will elaborate signalings regulated by Caveolin-1 in tumor cells.