中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
6期
36-39
,共4页
丁玉梅%马丽丽%窦洪涛%王新美%丁宁%于小辉
丁玉梅%馬麗麗%竇洪濤%王新美%丁寧%于小輝
정옥매%마려려%두홍도%왕신미%정저%우소휘
宫颈癌%Survivin%表达
宮頸癌%Survivin%錶達
궁경암%Survivin%표체
Cervical carcinoma%Survivin%Expression
目的：检测人宫颈正常组织、宫颈上皮内瘤变（Cervical intraepithelial neoplasia，CIN）以及宫颈癌组织中survivin蛋白的表达定位，研究该因子与宫颈癌发生发展的关系和临床应用价值。方法：收集2年间某医院97例患者的石蜡组织标本，其中正常宫颈组织20例、CIN25例、宫颈癌52例。采用免疫组化方法检测组织切片中的survivin蛋白，研究该因子在组织中的蛋白表达定位。结果：在宫颈组织中，survivin蛋白在胞核以及胞浆内均可见阳性染色，主要定位于细胞核。正常组survivin阳性率为5.0%，CIN组阳性率为56.0%，宫颈癌组阳性率为82.7%。survivin在宫颈癌组织中的高表达，与宫颈癌的临床分期、病理分化以及淋巴结转移均呈正相关。结论：survivin与宫颈癌的发生发展密切相关，可能成为对人宫颈癌的预防、诊治，以及判断预后有价值的临床肿瘤相关指标。
目的：檢測人宮頸正常組織、宮頸上皮內瘤變（Cervical intraepithelial neoplasia，CIN）以及宮頸癌組織中survivin蛋白的錶達定位，研究該因子與宮頸癌髮生髮展的關繫和臨床應用價值。方法：收集2年間某醫院97例患者的石蠟組織標本，其中正常宮頸組織20例、CIN25例、宮頸癌52例。採用免疫組化方法檢測組織切片中的survivin蛋白，研究該因子在組織中的蛋白錶達定位。結果：在宮頸組織中，survivin蛋白在胞覈以及胞漿內均可見暘性染色，主要定位于細胞覈。正常組survivin暘性率為5.0%，CIN組暘性率為56.0%，宮頸癌組暘性率為82.7%。survivin在宮頸癌組織中的高錶達，與宮頸癌的臨床分期、病理分化以及淋巴結轉移均呈正相關。結論：survivin與宮頸癌的髮生髮展密切相關，可能成為對人宮頸癌的預防、診治，以及判斷預後有價值的臨床腫瘤相關指標。
목적：검측인궁경정상조직、궁경상피내류변（Cervical intraepithelial neoplasia，CIN）이급궁경암조직중survivin단백적표체정위，연구해인자여궁경암발생발전적관계화림상응용개치。방법：수집2년간모의원97례환자적석사조직표본，기중정상궁경조직20례、CIN25례、궁경암52례。채용면역조화방법검측조직절편중적survivin단백，연구해인자재조직중적단백표체정위。결과：재궁경조직중，survivin단백재포핵이급포장내균가견양성염색，주요정위우세포핵。정상조survivin양성솔위5.0%，CIN조양성솔위56.0%，궁경암조양성솔위82.7%。survivin재궁경암조직중적고표체，여궁경암적림상분기、병리분화이급림파결전이균정정상관。결론：survivin여궁경암적발생발전밀절상관，가능성위대인궁경암적예방、진치，이급판단예후유개치적림상종류상관지표。
Objective:To observe the expression and location of survivin protein in human normal cervices,cervical intraepithelial neoplasia and cervical carcinoma,the relationship of survivin with the occurrence,development and prognostic of cervical carcinoma,and the clinical value of survivin for cervical carcinoma. Method:All of the paraffin tissue samples were gathered from one hospital in two years. The samples were divided three groups, 20 cases of normal cervices,25 cases of cervical intraepithelial neoplasia,and 52 cases of cervical carcinoma. The stains of survivin protein in the tissue samples with the immunohistochemistry methods were checked. Result:The stains of survivin in cervical tissue samples were located in cell nucleus and cytoplasm,mainly in cell nucleus. The positive rate of survivin was 5.0%in normal cervices,56.0%in cervical intraepithelial neoplasia,82.7%in cervical carcinoma. The correlation could be found of survivin with the clinical stage,histological differentiation and lymphatic metastasis of the cervical carcinoma. Conclusion:The correlation can be find of survivin with the occurance and progression the cervical carcinoma closely. Survivin will be a clinic valuable marker for the prevention,diagnosis,treatment,and judging the prognosis of human cervical carcinoma.
