检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
9期
1156-1158
,共3页
结核病%耐药%痰涂片%药敏检测
結覈病%耐藥%痰塗片%藥敏檢測
결핵병%내약%담도편%약민검측
tuberculosis%drug-resistance%sputum smear%drug susceptibility test
目的：探讨耐药结核病的流行状况，为耐药结核病的防治提供有效的科学依据。方法2012年3月至2013年3月于北京市设立各个监测点，再由相关医院确诊痰涂片检测为阳性的肺结核患者中，抽样选取164例作为研究对象，进行药敏检测与数据统计。结果结核病患者对一线药物的耐药率，如异烟肼（IN H ）、链霉素（SM）、利福平（RFP）、乙胺丁醇（EMB）等，其初治组患者明显低于复治组患者，差异有统计学意义（P＜0．05）；但是结核病初治组患者仅对IN H、RFP、SM和IN H、RFP、SM、EMB两种治疗方案耐药，其初、复治组患者对3种治疗方案耐多药率相比差异有统计学意义（P＜0．05）。初治组患者对SM的耐药率（23．86％）最高，而复治组患者对INH的耐药最高（42．11％），两组比较差异有统计学意义（χ2＝5．38，P＜0．05）。结论北京市结核病的耐药状况需有针对性的对相关问题进行改善，方能对耐药结核病的流行起到抑制作用。
目的：探討耐藥結覈病的流行狀況，為耐藥結覈病的防治提供有效的科學依據。方法2012年3月至2013年3月于北京市設立各箇鑑測點，再由相關醫院確診痰塗片檢測為暘性的肺結覈患者中，抽樣選取164例作為研究對象，進行藥敏檢測與數據統計。結果結覈病患者對一線藥物的耐藥率，如異煙肼（IN H ）、鏈黴素（SM）、利福平（RFP）、乙胺丁醇（EMB）等，其初治組患者明顯低于複治組患者，差異有統計學意義（P＜0．05）；但是結覈病初治組患者僅對IN H、RFP、SM和IN H、RFP、SM、EMB兩種治療方案耐藥，其初、複治組患者對3種治療方案耐多藥率相比差異有統計學意義（P＜0．05）。初治組患者對SM的耐藥率（23．86％）最高，而複治組患者對INH的耐藥最高（42．11％），兩組比較差異有統計學意義（χ2＝5．38，P＜0．05）。結論北京市結覈病的耐藥狀況需有針對性的對相關問題進行改善，方能對耐藥結覈病的流行起到抑製作用。
목적：탐토내약결핵병적류행상황，위내약결핵병적방치제공유효적과학의거。방법2012년3월지2013년3월우북경시설립각개감측점，재유상관의원학진담도편검측위양성적폐결핵환자중，추양선취164례작위연구대상，진행약민검측여수거통계。결과결핵병환자대일선약물적내약솔，여이연정（IN H ）、련매소（SM）、리복평（RFP）、을알정순（EMB）등，기초치조환자명현저우복치조환자，차이유통계학의의（P＜0．05）；단시결핵병초치조환자부대IN H、RFP、SM화IN H、RFP、SM、EMB량충치료방안내약，기초、복치조환자대3충치료방안내다약솔상비차이유통계학의의（P＜0．05）。초치조환자대SM적내약솔（23．86％）최고，이복치조환자대INH적내약최고（42．11％），량조비교차이유통계학의의（χ2＝5．38，P＜0．05）。결론북경시결핵병적내약상황수유침대성적대상관문제진행개선，방능대내약결핵병적류행기도억제작용。
Objective To study the prevalence of drug-resistant tuberculosis and to provide effective and scien-tific basis for prevention and control of drug-resistant tuberculosis .Methods Monitoring-stations were set up in counties and districts of certain city between March 2012 and March 2013 .A total of 164 pulmonary tuberculosis pa-tients ,whose sputum smears were with positive diagnosis ,were selected as research objects by random sampling for drug susceptibility test and data analysis .Results Drug-resistant rate to first-line drugs ,such as isonicotinyl hydra-zide(INH) ,rifampicin(RFP) ,ethambutol(EMB) and streptomycin(SM ) ,of tuberculosis patients with initial treat-ment was significantly lower than that of patients with re-treatment(P<0 .05) .But only two kinds of multi-drug re-sistance were identified ,including resistance to INH ,RFP ,EMB ,and resistance to INH ,RFP ,SM ,EMB ,and the multi-drug resistance rates were with significant difference between patients with initial treatment and patients with re-treatment(P<0 .05) .Drug- resistance rate of tuberculosis patients with initial treatment to SM was the highest (23 .86% ) ,but of patients with re-treatment ,resistance rate to INH was the highest(42 .11% ) ,and there was signifi-cant difference between the two groups(χ2 =5 .38 ,P<0 .05) .Conclusion The status of drug resistance of tuberculo-sis in this city should be targeted improved to inhibit the prevalence of drug-resistant tuberculosis .
