国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2014年
3期
559-561
,共3页
罗浩%楼倚天%潘冰心%张敏
囉浩%樓倚天%潘冰心%張敏
라호%루의천%반빙심%장민
角膜%干燥综合征%泪膜%泪膜破裂时间%泪液分泌试验
角膜%榦燥綜閤徵%淚膜%淚膜破裂時間%淚液分泌試驗
각막%간조종합정%루막%루막파렬시간%루액분비시험
cornea%Sj?gren's syndrome%tear film%tear break-up time%Schirmer I test
目的:研究不同发病年龄组及不同病程组的原发干燥综合征( Sj?gren's syndrome ,SS)眼部表现的差异,以探讨SS患者的泪液功能和角结膜状况及其影响因素。<br> 方法:回顾性分析SS患者80例160眼,根据病程将其分为3组:A组患者病程≤1a,B组患者病程1~2a,C组患者病程>2a,同时根据年龄将其分4个组:A组14~30岁, B组31~45岁,C组46~60岁,D组61~75岁,对比分析各组角膜荧光素染色(cornea fluorescein,CF)、泪膜破裂时间( break-up time, BUT )及 Schirmer 试验( Schirmer Ⅰtest,SⅠt)检查以及干眼症出现情况。<br> 结果:SS患者干眼症患病率为38%,明显高于普通人群,干眼症患病率随发病年龄的增大(χ2=10.66, P=0.014)及病程的延长(χ2=20.127,P=0.000)而增加。 SⅠt随发病年龄的增大(H=2.575,P=0.462)及病程的延长(H=7.356,P=0.025)而减少,BUT随发病年龄的增大(H=11.932,P=0.008)及病程的延长(H=12.969,P=0.002)而缩短,CF随发病年龄的增大( H=14.068, P=0.003)及病程的延长(H=16.060,P=0.000)而加重。<br> 结论:SS患者易继发干眼症。 SS患者的眼表改变表现为泪液的质和量的失调,泪膜稳定性下降,泪液分泌量下降,角膜荧光素着色,上述变化与发病年龄和病程成正相关。BUT、SⅠt、CF检查有必要作为SS患者的眼科常规检查。
目的:研究不同髮病年齡組及不同病程組的原髮榦燥綜閤徵( Sj?gren's syndrome ,SS)眼部錶現的差異,以探討SS患者的淚液功能和角結膜狀況及其影響因素。<br> 方法:迴顧性分析SS患者80例160眼,根據病程將其分為3組:A組患者病程≤1a,B組患者病程1~2a,C組患者病程>2a,同時根據年齡將其分4箇組:A組14~30歲, B組31~45歲,C組46~60歲,D組61~75歲,對比分析各組角膜熒光素染色(cornea fluorescein,CF)、淚膜破裂時間( break-up time, BUT )及 Schirmer 試驗( Schirmer Ⅰtest,SⅠt)檢查以及榦眼癥齣現情況。<br> 結果:SS患者榦眼癥患病率為38%,明顯高于普通人群,榦眼癥患病率隨髮病年齡的增大(χ2=10.66, P=0.014)及病程的延長(χ2=20.127,P=0.000)而增加。 SⅠt隨髮病年齡的增大(H=2.575,P=0.462)及病程的延長(H=7.356,P=0.025)而減少,BUT隨髮病年齡的增大(H=11.932,P=0.008)及病程的延長(H=12.969,P=0.002)而縮短,CF隨髮病年齡的增大( H=14.068, P=0.003)及病程的延長(H=16.060,P=0.000)而加重。<br> 結論:SS患者易繼髮榦眼癥。 SS患者的眼錶改變錶現為淚液的質和量的失調,淚膜穩定性下降,淚液分泌量下降,角膜熒光素著色,上述變化與髮病年齡和病程成正相關。BUT、SⅠt、CF檢查有必要作為SS患者的眼科常規檢查。
목적:연구불동발병년령조급불동병정조적원발간조종합정( Sj?gren's syndrome ,SS)안부표현적차이,이탐토SS환자적루액공능화각결막상황급기영향인소。<br> 방법:회고성분석SS환자80례160안,근거병정장기분위3조:A조환자병정≤1a,B조환자병정1~2a,C조환자병정>2a,동시근거년령장기분4개조:A조14~30세, B조31~45세,C조46~60세,D조61~75세,대비분석각조각막형광소염색(cornea fluorescein,CF)、루막파렬시간( break-up time, BUT )급 Schirmer 시험( Schirmer Ⅰtest,SⅠt)검사이급간안증출현정황。<br> 결과:SS환자간안증환병솔위38%,명현고우보통인군,간안증환병솔수발병년령적증대(χ2=10.66, P=0.014)급병정적연장(χ2=20.127,P=0.000)이증가。 SⅠt수발병년령적증대(H=2.575,P=0.462)급병정적연장(H=7.356,P=0.025)이감소,BUT수발병년령적증대(H=11.932,P=0.008)급병정적연장(H=12.969,P=0.002)이축단,CF수발병년령적증대( H=14.068, P=0.003)급병정적연장(H=16.060,P=0.000)이가중。<br> 결론:SS환자역계발간안증。 SS환자적안표개변표현위루액적질화량적실조,루막은정성하강,루액분비량하강,각막형광소착색,상술변화여발병년령화병정성정상관。BUT、SⅠt、CF검사유필요작위SS환자적안과상규검사。
AIM:To analyze the difference of ocular manifestations in Sj?gren's syndrome ( SS) of different age groups and different disease courses.And investigate whether SS is correlated with tear dysfunction and ocular surface disorder. <br> METHODS: Retrospective analysis of 80 patients ( 160 eyes) with SS.The cases were divided into three groups according to the course.Group A: course of disease ≤1a.Group B: course of disease from 1 to 2a; Group C:course of disease >2a.At the same time, cases were divided into four groups according to the age, group A:15-30 years old;Group B:31-45 years old;Group C:46-60 years old; Group D: 61 -75 years old. The data including the staining of cornea fluorescein ( CF) , the tear break-up time (BUT), Schirmer Ⅰ test (SⅠt) and the occurrence of dry eye were collected and compared. <br> RESULTS: Prevalence of dry eye with SS was 36%, significantly higher than the general population. The prevalence of dry eye increased with increasing age (χ2=10.66, P=0.014) and extension of course (χ2=20.127, P=0.000), the secretion of tear decreased with increasing age ( H=2.575, P=0.462 ) and extension of course ( H=7.356, P=0.025) and the tear film break-up time become shorter with increasing age ( H=11.932, P=0.008 ) and extension of course (H=12.969, P=0.002), the degree of staining with fluorescin on the cornea increased with increasing age ( H=14.068, P=0.003) and extension of course (H=16.060, P=0.000). <br> CONCLUSION:Patients with SS are susceptible persons of the dry eye. The ocular surface disease in SS is characterized by a disorder of tear quantity and quality, decreased tear film stability, decreased secretion of the tear, staining with fluorescin on the cornea. The correlation of these changes and age and course is positive.BUT, SⅠt and CF should become routine tests of ophthalmology in SS.