CAJ | 학술논문

目的：观察白内障超声乳化手术对伴有糖尿病或高血压的白内障患者角膜内皮细胞的影响。 　　方法：采用临床病例对照研究，将白内障超声乳化手术患者104例174眼分为三组：单纯老年性白内障组（对照组）、老年性白内障伴发糖尿病组（糖尿病组）及老年性白内障伴发高血压组（高血压组），观察超声乳化术前、术后1 wk；1 mo角膜内皮细胞密度、六角形细胞比例、细胞变异系数等各参数的变化，采用SPSS 13．0统计学软件对数据进行统计学分析。 　　结果：术前，与对照组相比，糖尿病组及高血压组角膜内皮细胞密度降低，六角形细胞比例下降，细胞变异系数增加，其中糖尿病组变异系数和六角形细胞比例变化与对照组间数据差异有统计学意义（均P＜0．05），高血压组六角形细胞比例变化与对照组间数据差异有统计学意义（P＜0.05）；术后，各组术后1 wk和1 mo角膜内皮细胞密度及六角形细胞比例均较术前明显下降，变异系数均较术前增大，差异均有显著性意义（均P＜0．01）。其中糖尿病组与对照组内皮细胞密度间差异具有统计学意义（P＜0．05），六角形细胞比例及变异系数间数据具有显著性差异（均P＜0.01）。高血压组与对照组六角形细胞比例和变异系数间数据均有显著性差异（均P＜0．01）。 　　结论：白内障超声乳化术对角膜内皮细胞具有一定的损伤性，伴有高血压或糖尿病的白内障患者角膜内皮细胞更易受到损伤。对超声乳化术后产生的损伤也更为敏感。
목적：관찰백내장초성유화수술대반유당뇨병혹고혈압적백내장환자각막내피세포적영향。 　　방법：채용림상병례대조연구，장백내장초성유화수술환자104례174안분위삼조：단순노년성백내장조（대조조）、노년성백내장반발당뇨병조（당뇨병조）급노년성백내장반발고혈압조（고혈압조），관찰초성유화술전、술후1 wk；1 mo각막내피세포밀도、륙각형세포비례、세포변이계수등각삼수적변화，채용SPSS 13．0통계학연건대수거진행통계학분석。 　　결과：술전，여대조조상비，당뇨병조급고혈압조각막내피세포밀도강저，륙각형세포비례하강，세포변이계수증가，기중당뇨병조변이계수화륙각형세포비례변화여대조조간수거차이유통계학의의（균P＜0．05），고혈압조륙각형세포비례변화여대조조간수거차이유통계학의의（P＜0.05）；술후，각조술후1 wk화1 mo각막내피세포밀도급륙각형세포비례균교술전명현하강，변이계수균교술전증대，차이균유현저성의의（균P＜0．01）。기중당뇨병조여대조조내피세포밀도간차이구유통계학의의（P＜0．05），륙각형세포비례급변이계수간수거구유현저성차이（균P＜0.01）。고혈압조여대조조륙각형세포비례화변이계수간수거균유현저성차이（균P＜0．01）。 　　결론：백내장초성유화술대각막내피세포구유일정적손상성，반유고혈압혹당뇨병적백내장환자각막내피세포경역수도손상。대초성유화술후산생적손상야경위민감。
AIM: To observe the influence of cataract phacoemulsification on corneal endothelial cell of cataract patients combined with diabetes or hypertension. METHODS: Clinical case -control study was used. Totally 104 cases (174 eyes) of patients who underwent phacoemulsification were divided into three groups:senile cataract patients, diabetes mellitus cataract patients and hypertension cataract patients. The changes of endothelial cell density ( CD ) , percentage of regular hexagonal cells ( 6A ), coefficient of variation ( CV ) between pre-operation and post-operation at 1wk, 1mo were compared.The data were analyzed statistically by means of SPSS 13.0 software. RESULTS: Pre-operative results: the percentage of CD and 6A cell were decreased and CV was increased in diabetes and hypertension group compared with control group.There were statistical differences in 6A and CV in diabetes group ( P <0.05 ). There were statistical differences in 6A in hypertension group (P<0.05).Post-operative results: the percentage of CD and 6A were decreased, and CV was increased after operation of 1wk and 1mo. There were significant differences in three groups ( P<0.01 ).CD had statistical differences ( P<0.05), CV and 6A had significant differences (P<0.01) between diabetes group and control group.6A and CV had significant differences ( P <0. 01 ) between hypertension group and control group. CONCLUSION:Cataract phacoemulsification has certain injury on corneal endothelial cell. Cataract patients combined with diabetes or hypertension are easier to be damaged than that of senile cataract in the phacoemulsification. They are more sensitive after surgery.