CAJ | 학술논문

视网膜色素上皮（ retinal pigment epithelium ，RPE）为一单层排列整齐的六角柱形细胞所组成，位于神经视网膜的光感受器和脉络膜的Bruch's膜之间，在维持光感受器细胞存活和正常功能方面起重要作用。多种先天性视网膜色素上皮疾病的发生与胚胎期的发育发生有着密切的关系。本文对RPE胚胎发育的基本过程、诱导RPE发生发育的信号分子、调控RPE发生发育的基因及维持RPE分化的信号通路等几个方面做一综述。
시망막색소상피（ retinal pigment epithelium ，RPE）위일단층배렬정제적륙각주형세포소조성，위우신경시망막적광감수기화맥락막적Bruch's막지간，재유지광감수기세포존활화정상공능방면기중요작용。다충선천성시망막색소상피질병적발생여배태기적발육발생유착밀절적관계。본문대RPE배태발육적기본과정、유도RPE발생발육적신호분자、조공RPE발생발육적기인급유지RPE분화적신호통로등궤개방면주일종술。
The retinal pigment epithelium ( RPE ) is a pigmented simplecuboidal monolayer of epithelial cells that located between the photoreceptors in the neural retina and the Bruch's membrane in the vascular choroid and is critical for the survival and function of retinal photoreceptors. The pathogenesis of multiple congenital RPE diseases is closely related to embryonic development.This review summarized the current knowledge of the molecular mechanisms controlling early steps of RPE development, with emphasis on basic process, critical signaling molecules, key transcription factors and pathway maintaining the RPE cell fate.