CAJ | 학술논문

目的：研究舒芬太尼对兔眼部用药的急性毒性反应，为其临床局部安全用药提供理论依据。 　　方法：将16只健康成年新西兰兔随机分成4组。1组为对照组，以空白溶剂作溶媒对照；2，3，4组家兔左眼分别滴舒芬太尼注射液5μg（2滴，5min 内）、7．5μg（3滴，10min内）、10μg（4滴，15min内），同时各组右眼以9g/L NaCl溶液作为自身对照，滴速相同。滴药后的7 d后进行局部毒性研究。 　　结果：肉眼及裂隙灯观察：各组角膜无混浊、结膜无明显充血和水肿、无分泌物、虹膜正常，无产生暂时闭目现象。内皮照相：各组的角膜内皮细胞计数无统计学差异；光镜观察：结膜、角膜、角巩缘、虹膜、睫状体、视网膜及视神经均未发现有病理形态学损伤。 　　结论：单次使用5～10μg 舒芬太尼眼部给药进行镇静、镇痛在短期内是安全的。
목적：연구서분태니대토안부용약적급성독성반응，위기림상국부안전용약제공이론의거。 　　방법：장16지건강성년신서란토수궤분성4조。1조위대조조，이공백용제작용매대조；2，3，4조가토좌안분별적서분태니주사액5μg（2적，5min 내）、7．5μg（3적，10min내）、10μg（4적，15min내），동시각조우안이9g/L NaCl용액작위자신대조，적속상동。적약후적7 d후진행국부독성연구。 　　결과：육안급렬극등관찰：각조각막무혼탁、결막무명현충혈화수종、무분비물、홍막정상，무산생잠시폐목현상。내피조상：각조적각막내피세포계수무통계학차이；광경관찰：결막、각막、각공연、홍막、첩상체、시망막급시신경균미발현유병리형태학손상。 　　결론：단차사용5～10μg 서분태니안부급약진행진정、진통재단기내시안전적。
AIM: To investigate the ocular acute toxicity of sufentanil in rabbits, in order to provide the scientific basis for its safe administration and reasonable combination. METHODS: Sixteen healthy rabbits were randomly divided into 4 groups (groups 1-4), control (vehicle), low (5μg, 2 drops in 5min), moderate (7.5μg, 3 drops in 10min) and high doses (10μg, 4 drops in 15min) of sufentanil-treated groups. Solvent without sufentanil was administered to the left eyes in the vehicle control group (group 1).Meanwhile, 9g/L NaCl solutions were given to the right eyes in all 4 groups at equal drip rate for auto-control.After 7d, ocular toxicity was firstly evaluated. RESULTS:Observed with naked eye and slit lamp, no changes including corneal opacity, conjunctival congestion, chemosis, eye secretions, iris abnormalities and temporal eye closed was in all groups.With slit-lamp microscope, the counts of corneal endothelium cells in all groups have no statistically significant difference.With light microscope, no pathomorphological injury in the conjunctiva, cornea, corneoscleral junction, iris, ciliary body, retina and optic nerve were found. CONCLUSION: The ophthalmic application of sufentanil alone (5-10μg) for sedation and analgesia is safe in a short period.