CAJ | 학술논문

目的：对比研究叶酸片联合常规降压和单纯常规降压对老年 H 型高血压患者骨密度及动脉粥样硬化的影响。方法选取60例老年 H 型高血压患者，随机分为试验组和对照组各30例。两组均口服常规降压药，试验组加服叶酸片，疗程均为6个月。治疗前后分别测量患者血压、血浆同型半胱氨酸(Hcy)水平、骨密度值(BMd)、颈动脉内膜厚度(iMt)，治疗期间连续随访记录不良反应和心脑血管事件以及骨折的发生情况。结果两组降压效果比较，差异无统计学意义(P＞0.05)；试验组降 Hcy 有效率高于对照组，差异有统计学意义(P ＜0.05)；试验组 BMd 升高，差异有统计学意义(P＜0.05)；试验组 iMt 降低，差异有统计学意义(P ＜0.05)；随访期间试验组心脑血管事件发生率低于对照组，差异有统计学意义(P ＜0.05)；试验组无骨折发生，对照组1例，差异无统计学意义(P>0.05)。结论叶酸片降 Hcy 水平效果显著，同时可以有效减缓动脉硬化的进展，升高骨密度值，有效减少心脑血管事件发生率。
목적：대비연구협산편연합상규강압화단순상규강압대노년 H 형고혈압환자골밀도급동맥죽양경화적영향。방법선취60례노년 H 형고혈압환자，수궤분위시험조화대조조각30례。량조균구복상규강압약，시험조가복협산편，료정균위6개월。치료전후분별측량환자혈압、혈장동형반광안산(Hcy)수평、골밀도치(BMd)、경동맥내막후도(iMt)，치료기간련속수방기록불량반응화심뇌혈관사건이급골절적발생정황。결과량조강압효과비교，차이무통계학의의(P＞0.05)；시험조강 Hcy 유효솔고우대조조，차이유통계학의의(P ＜0.05)；시험조 BMd 승고，차이유통계학의의(P＜0.05)；시험조 iMt 강저，차이유통계학의의(P ＜0.05)；수방기간시험조심뇌혈관사건발생솔저우대조조，차이유통계학의의(P ＜0.05)；시험조무골절발생，대조조1례，차이무통계학의의(P>0.05)。결론협산편강 Hcy 수평효과현저，동시가이유효감완동맥경화적진전，승고골밀도치，유효감소심뇌혈관사건발생솔。
Objective this dissertation investigates the effects of folic acid tablet combined conventional decompression in comparison with the influences of simple routine decompression on bone mineral density as well as atherosclerosis in patients with elderly H-type hypertension. Methods 60 cases of patients with elderly H-type hypertension were randomly divided into 2 groups, treatment group and control group, with 30 cases in each group. All of two groups’patients were given routine antihypertensive drugs. treatment group added folic acid tablets. the courses were both 6 months. Mensurate patients’blood pressure, level of homocysteine (Hcy), bone mineral density (BdM), intimamedia thickness (iMt) before and after the treatment; follow and record the untoward effects, cardiovascular and cerebrovascular events and conditions of fracture. results With the comparison of two-groups effects, the final difference had no statistical significance (P > 0.05). during the period to fall Hcy, treatment group shows a higher effectivity than control group; the difference had statistical significance (P < 0.05). BDM of treatment group rises; the difference had statistical significance (P < 0.05). iMB of treatment group decreases; the difference had statistical significance (P < 0.05). the incidence of cardiovascular and cerebrovascular events was lower than the that of control group during the follow-up period; the difference had statistical significance (P < 0.05). nobody in treatment group got fracture, but one case happened in control group; the difference had no statistical significance (P > 0.05). Conclusion folic acid tablets show a significant effect on the decline of Hcy. Meanwhile folic acid tablets can retard the progress of arteriosclerosis, enhance the BdM, and reduce incidence of cardiovascular and cerebrovascular events effectively.