中国老年保健医学
中國老年保健醫學
중국노년보건의학
CHINESE JOURNAL OF GERIATRIC CARE
2014年
1期
22-23,24
,共3页
急性脑梗死%N末端B型钠尿肽原%心型脂肪酸结合蛋白%临床价值
急性腦梗死%N末耑B型鈉尿肽原%心型脂肪痠結閤蛋白%臨床價值
급성뇌경사%N말단B형납뇨태원%심형지방산결합단백%림상개치
ACI%NT-proBNP%h-FABP%Clinical value
目的：通过观察急性期脑梗死（ ACI ）患者血清N末端B型钠尿肽原（ NT-proBNP ）和心型脂肪酸结合蛋白（ h-FABP）水平变化，探讨其伴发早期心功能及心肌细胞损害的监测价值。方法选择95例ACI患者和50例健康对照组为研究对象，血清NT-proBNP检测采用电化学发光免疫分析（ ECLIA）法，血清h-FABP检测采用双抗体夹心酶联免疫（ ELISA）一步法。结果①血清NT-proBNP和h-FABP水平，ACI患者急性期显著高于恢复期及对照组（P＜0.01）；大面积ACI患者显著高于小面积ACI患者（P＜0.01）；恢复期患者与对照组相比，差异无显著性（P＞0.05）。②ACI急性期患者血清NT-proB-NP阳性率（54.74％）显著低于血清h-FABP的阳性率（82.11％）（P＜0.01），且两者具有相关一致性。③ACI急性期患者血清h-FABP水平与NT-proBNP呈显著正相关（r＝0.719，P＜0.01），相关性良好。结论 ACI急性期患者血清NT-proBNP和h-FABP水平显著升高，且具有相关性，联合检测其水平变化，对诊断ACI并发早期心功能及心肌细胞损害具有临床检测价值。
目的：通過觀察急性期腦梗死（ ACI ）患者血清N末耑B型鈉尿肽原（ NT-proBNP ）和心型脂肪痠結閤蛋白（ h-FABP）水平變化，探討其伴髮早期心功能及心肌細胞損害的鑑測價值。方法選擇95例ACI患者和50例健康對照組為研究對象，血清NT-proBNP檢測採用電化學髮光免疫分析（ ECLIA）法，血清h-FABP檢測採用雙抗體夾心酶聯免疫（ ELISA）一步法。結果①血清NT-proBNP和h-FABP水平，ACI患者急性期顯著高于恢複期及對照組（P＜0.01）；大麵積ACI患者顯著高于小麵積ACI患者（P＜0.01）；恢複期患者與對照組相比，差異無顯著性（P＞0.05）。②ACI急性期患者血清NT-proB-NP暘性率（54.74％）顯著低于血清h-FABP的暘性率（82.11％）（P＜0.01），且兩者具有相關一緻性。③ACI急性期患者血清h-FABP水平與NT-proBNP呈顯著正相關（r＝0.719，P＜0.01），相關性良好。結論 ACI急性期患者血清NT-proBNP和h-FABP水平顯著升高，且具有相關性，聯閤檢測其水平變化，對診斷ACI併髮早期心功能及心肌細胞損害具有臨床檢測價值。
목적：통과관찰급성기뇌경사（ ACI ）환자혈청N말단B형납뇨태원（ NT-proBNP ）화심형지방산결합단백（ h-FABP）수평변화，탐토기반발조기심공능급심기세포손해적감측개치。방법선택95례ACI환자화50례건강대조조위연구대상，혈청NT-proBNP검측채용전화학발광면역분석（ ECLIA）법，혈청h-FABP검측채용쌍항체협심매련면역（ ELISA）일보법。결과①혈청NT-proBNP화h-FABP수평，ACI환자급성기현저고우회복기급대조조（P＜0.01）；대면적ACI환자현저고우소면적ACI환자（P＜0.01）；회복기환자여대조조상비，차이무현저성（P＞0.05）。②ACI급성기환자혈청NT-proB-NP양성솔（54.74％）현저저우혈청h-FABP적양성솔（82.11％）（P＜0.01），차량자구유상관일치성。③ACI급성기환자혈청h-FABP수평여NT-proBNP정현저정상관（r＝0.719，P＜0.01），상관성량호。결론 ACI급성기환자혈청NT-proBNP화h-FABP수평현저승고，차구유상관성，연합검측기수평변화，대진단ACI병발조기심공능급심기세포손해구유림상검측개치。
Objective Through the observation of the acute phase ACI patients serum NT-proBNP and h-FABP level change , discuss the accompanying early cardiac function and myocardial cell damage monitoring value .Methods The method and ELISA re-spectively ECLIA step method ,tested the 95 cases of ACI patients and fifty cases of control group serum NT-proBNP and h-FABP level.Results ACI patients with the acute phase of serum NT-proBNP and h-FABP level were significantly higher than those in the control group(P<0.01),is also significantly higher recovery ACI patients (P<0.01),CI monitoring patients compared with no sig-nificant difference ( P>0.05) .Large areas of ACI patients serum NT-proBNP and h-FABP level were significantly higher than the small area of ACI patients(P<0.01).ACI patients with the acute phase of serum NT-proBNP positive rate(54.74%)significantly lower than serum h-FABP positive rate of(82.11%)(P<0.01),and the related consistency.ACI patients with the acute phase of serum h-FABP level and NT-proBNP is a significant positive correlation ( r =0.719, P <0.01 ), and the correlation is good.Conclusion ACI patients with the acute phase of serum NT-proBNP and h-FABP level increased significantly ,and has rele-vance,joint detection its level can timely know concurrent early myocardial cell damage and cardiac function ,to guide treatment and improve prognosis is of great significance.
