CAJ | 학술논문

非小细胞肺癌（non-small cell lung cancer, NSCLC）作为全球癌症相关死亡率较高的恶性肿瘤，目前仍缺少可靠稳定的预后指标。血小板源生长因子（platelet derived grow factor, PDGF）及其受体通过多种细胞内信号通路参与细胞生长，迁移，转移以及上皮间叶转化等过程。病理结果表明，PDGF通路主要通过旁分泌途径刺激NSCLC肿瘤间质生长，亦有发现PDGF通路对某些NSCLC肿瘤细胞可能存在直接驱动作用。NSCLC组织中的PDGF及其受体的表达与肿瘤的预后，淋巴结转移等临床结果相关。在临床治疗中，PDGF通路对NSCLC血管生成的重要作用，及抑制PDGF通路促进化疗药物在实体瘤内部分布的作用不容忽视。PDGF作为重要的促血管生成通路，在NSCLC放射治疗中的作用也越来越多地被各种基础研究证实。本文拟对PDGF通路在NSCLC领域的研究进展做一综述，以求对临床和基础研究者有一些启发。
비소세포폐암（non-small cell lung cancer, NSCLC）작위전구암증상관사망솔교고적악성종류，목전잉결소가고은정적예후지표。혈소판원생장인자（platelet derived grow factor, PDGF）급기수체통과다충세포내신호통로삼여세포생장，천이，전이이급상피간협전화등과정。병리결과표명，PDGF통로주요통과방분비도경자격NSCLC종류간질생장，역유발현PDGF통로대모사NSCLC종류세포가능존재직접구동작용。NSCLC조직중적PDGF급기수체적표체여종류적예후，림파결전이등림상결과상관。재림상치료중，PDGF통로대NSCLC혈관생성적중요작용，급억제PDGF통로촉진화료약물재실체류내부분포적작용불용홀시。PDGF작위중요적촉혈관생성통로，재NSCLC방사치료중적작용야월래월다지피각충기출연구증실。본문의대PDGF통로재NSCLC영역적연구진전주일종술，이구대림상화기출연구자유일사계발。
Non-small cell lung cancer (NSCLC) is a malignant tumour with quite high cancer speciifc mortality, and it still lacks stable and reliable markers for NSCLC's prognosis. Platelet derived grow factor (PDGF) and PDGFR has been considered to be involved in the process of cell proliferation, migration, metastasis and epithelial mesenchymal transition of cancer cell through various intracellular signal pathways. Pathology analysis showed that PDGF pathway mainly stimulates the proliferation of NSCLC tumour stroma through paracrine pattern, and some reaseach found that PDGF pathway directly pro-motes some NSCLC cell's proliferation. hTe expression of PDGF and PDGFR within NSCLC tissue correlates with status of lymphatic metastasis and patients’ prognosis. In clinical treatment of NSCLC, the great effect of PDGF pathway in angiogenesis and promoting distribution of chemotherapy by inhibition of PDGF should not be neglected. As an important pro-angiogen-esis pathway, functions of PDGF in radiotherapy is dicovered by more and more fundamental research. hTis review focuses on the progress of PDGF pathway in NSCLC and aims to provide some new ideas for clinical and fundamental researchers.