CAJ | 학술논문

目的：探讨不稳定型心绞痛患者行PCI介入治疗前早期（3个月）应用曲美他嗪对PCI围手术期心肌的保护作用。方法150例不稳定型心绞痛患者随机分为曲美他嗪组和对照组。曲美他嗪组在常规药物基础上，于术前3个月开始口服曲美他嗪（20 mg，tid）。两组均于术前、术后1 h、术后1 d记录同步12导联心电图；于PCI术前、术后6、12、24、48 h测定患者心肌肌钙蛋白I （cTnI）水平。结果最终纳入82例成功行PCI手术的不稳定型心绞痛患者（曲美他嗪组42例，对照组40例）。PCI术后曲美他嗪组cTnI水平低于对照组，差异有统计学意义（P＜0.05）；与对照组相比，曲美他嗪组PCI相关心肌梗死的发生率较低（5％ vs 15％，P＝0.028）。结论 PCI术前早期（3个月）服用曲美他嗪可以减少围手术期心肌损伤，降低PCI相关心肌梗死的发生率。
목적：탐토불은정형심교통환자행PCI개입치료전조기（3개월）응용곡미타진대PCI위수술기심기적보호작용。방법150례불은정형심교통환자수궤분위곡미타진조화대조조。곡미타진조재상규약물기출상，우술전3개월개시구복곡미타진（20 mg，tid）。량조균우술전、술후1 h、술후1 d기록동보12도련심전도；우PCI술전、술후6、12、24、48 h측정환자심기기개단백I （cTnI）수평。결과최종납입82례성공행PCI수술적불은정형심교통환자（곡미타진조42례，대조조40례）。PCI술후곡미타진조cTnI수평저우대조조，차이유통계학의의（P＜0.05）；여대조조상비，곡미타진조PCI상관심기경사적발생솔교저（5％ vs 15％，P＝0.028）。결론 PCI술전조기（3개월）복용곡미타진가이감소위수술기심기손상，강저PCI상관심기경사적발생솔。
Objective To explore the protective effect of early using Trimetazidine (TMZ)before percutaneous coronary intervention (PCI)on the unstable angina patients. Methods One hundred and fifty unstable angina patients were randomly divided to control group and trimetazidine treatment group. Patient in trimetazidine treatment group must take trmetazidine (20 mg,tid)for 3 months before PCI. 1 2-lead ECG was recorded before,1 h after PCI and the following day. The cardiac troponin I (cTnI)level were measured be-fore and 6、1 2、24、48 h after PCI. Results Totally 82 patients who successful undergo elective?PCI were finally enrolled,42 were assigned into TMZ group and 40 into control group. Compare to control group,the cT-nI level were significantly reduced in the TMZ group (P<0.05 ). The incidence of PCI-related myocardial in-farction (PMI)was significantly decreased in TMZ group (5%vs 1 5%,P=0.028). Conclusion Early u-sing TMZ before PCI on the unstable angina patients can decrease the damage to myocardium and reduce the in-cidence of PMI.