皖南医学院学报
皖南醫學院學報
환남의학원학보
ACTA ACADEMIAE MEDICINAE WANNAN
2014年
1期
36-39
,共4页
胎盘部位滋养细胞肿瘤%临床病理%鉴别诊断
胎盤部位滋養細胞腫瘤%臨床病理%鑒彆診斷
태반부위자양세포종류%림상병리%감별진단
placental site trophoblastic tumor%clinical pathology%differential diagnosis
目的：探讨胎盘部位滋养细胞肿瘤（ PSTT）的临床特征、病理特点、诊断及鉴别诊断，并分析与预后有关的形态学指标。方法：对1例PSTT的临床特征、病理形态及免疫组化特征进行分析并复习相关文献。结果：光镜下肿瘤细胞异常增殖，呈片状、条索状在子宫肌壁间浸润生长，并伴有特征性的血管侵犯，分裂象少见；免疫组化标记结果：肿瘤细胞PLAP、CK、EMA、β-HCG、α-inhibin均阳性，Vim、S-100、P53、Calponin、Des、SMA均阴性，ki-67阳性率为60％。结论：PSTT是一种罕见的具有特殊临床生物学行为及病理特征的妊娠滋养细胞肿瘤，可结合免疫组化染色结果与上皮样滋养细胞肿瘤、上皮样平滑肌肉瘤、透明细胞癌及血管周上皮样细胞肿瘤等鉴别。
目的：探討胎盤部位滋養細胞腫瘤（ PSTT）的臨床特徵、病理特點、診斷及鑒彆診斷，併分析與預後有關的形態學指標。方法：對1例PSTT的臨床特徵、病理形態及免疫組化特徵進行分析併複習相關文獻。結果：光鏡下腫瘤細胞異常增殖，呈片狀、條索狀在子宮肌壁間浸潤生長，併伴有特徵性的血管侵犯，分裂象少見；免疫組化標記結果：腫瘤細胞PLAP、CK、EMA、β-HCG、α-inhibin均暘性，Vim、S-100、P53、Calponin、Des、SMA均陰性，ki-67暘性率為60％。結論：PSTT是一種罕見的具有特殊臨床生物學行為及病理特徵的妊娠滋養細胞腫瘤，可結閤免疫組化染色結果與上皮樣滋養細胞腫瘤、上皮樣平滑肌肉瘤、透明細胞癌及血管週上皮樣細胞腫瘤等鑒彆。
목적：탐토태반부위자양세포종류（ PSTT）적림상특정、병리특점、진단급감별진단，병분석여예후유관적형태학지표。방법：대1례PSTT적림상특정、병리형태급면역조화특정진행분석병복습상관문헌。결과：광경하종류세포이상증식，정편상、조색상재자궁기벽간침윤생장，병반유특정성적혈관침범，분렬상소견；면역조화표기결과：종류세포PLAP、CK、EMA、β-HCG、α-inhibin균양성，Vim、S-100、P53、Calponin、Des、SMA균음성，ki-67양성솔위60％。결론：PSTT시일충한견적구유특수림상생물학행위급병리특정적임신자양세포종류，가결합면역조화염색결과여상피양자양세포종류、상피양평활기육류、투명세포암급혈관주상피양세포종류등감별。
Objective:To investigate the clinical characteristics, pathological behavior and differential diagnosis of placental site trophoblastic tumor (PSTT),and analyze the morphological indicators for prognosis of this entity.Methods:One case of PSTT was analyzed regarding its clinical features,path-omorphism and immunohistochemical findings,and the related literatures concerning this entity were reviewed.Results:Microscopically,the tumor cells were proliferated abnormally with little karyomitosis and infiltratively grown in the uterine muscles accompanied by characteristic vascular invasion .Immu-nohistochemical study showed that the tumor was positive for PLAP,CK,EMA,β-HCG andα-inhibin,yet negative for Vim,S-100,P53,Calponin,Des and SMA,and ki-67 positive cells accounted for 60%.Conclusion:PSTT is a rare gestational trophoblastic tumor with specific clinical biological behavior and pathological features.Additional immunohistochemical staining results may contribute to differential diagnosis of this entity from epithelioid trophoblastic tumor(ETT),epithelioid leiomyosarcoma(ELS),clear cell carcinoma and perivascular epithelioid cell neoplasms(PEComas).
