CAJ | 학술논문

目的：采用原子吸收分光光度法对玉米多糖铁在毕格犬体内的药代动力学特征进行研究。方法：毕格犬灌胃（11．0 mg/kg、5．7 mg/kg、2．9 mg/kg）给予玉米多糖铁后，不同时间点测定犬体内铁离子的浓度，所得数据用DAS软件求算药动学参数并分析。结果：当玉米多糖铁中铁离子浓度在0．2～5μg/ml范围内时其线性关系良好，标准曲线的相关系数r＝0．9996～0．9999，平均回收率达到91％以上、RSD值低于15％。药动学参数表明其在毕格犬体内的药动学模型符合二室模型，其中三个剂量组的t1/2分别为（1．69±0．25）×103、（1．4±0．51）×103和（1．88±1．41）×103 min；AUC0-∞分别为（5．87±1．39）×103、（4．53±1．11）×103和（3．91±2．12）×103 mg/（L· min）。结论：本研究数据为进一步研究玉米多糖铁的临床应用提供了极具价值的实验参数。
목적：채용원자흡수분광광도법대옥미다당철재필격견체내적약대동역학특정진행연구。방법：필격견관위（11．0 mg/kg、5．7 mg/kg、2．9 mg/kg）급여옥미다당철후，불동시간점측정견체내철리자적농도，소득수거용DAS연건구산약동학삼수병분석。결과：당옥미다당철중철리자농도재0．2～5μg/ml범위내시기선성관계량호，표준곡선적상관계수r＝0．9996～0．9999，평균회수솔체도91％이상、RSD치저우15％。약동학삼수표명기재필격견체내적약동학모형부합이실모형，기중삼개제량조적t1/2분별위（1．69±0．25）×103、（1．4±0．51）×103화（1．88±1．41）×103 min；AUC0-∞분별위（5．87±1．39）×103、（4．53±1．11）×103화（3．91±2．12）×103 mg/（L· min）。결론：본연구수거위진일보연구옥미다당철적림상응용제공료겁구개치적실험삼수。
Objective:To tentatively investigate the pharmacokinetics of corn polysaccharide iron complex (PIC) in beagle dogs.Methods:After intragas-tric administration of PIC(11.0 mg/kg,5.7 mg/kg,2.9 mg/kg)into the animals,atomic absorption spectrophotometry was used to detect the serum con-centration of the ferri ion at diverse time points,and the data were calculated with Debris Assessment Software(DAS,version 2.0) for analysis of the mean pharmacokinetic parameters.Results:The ferri ion concentration in PIC at the range of of 0.2-5 μg/ml demonstrated better linear relation to the standard curve(r=0.999 6-0.999 9),which led to an average recovery rate of over 91% and a relative standard deviation(RSD) lower than 15%.The pharma-cokinetic parameters at 3 different dosage were measured up with the two-compartment open model by t1/2(1.69 ±0.25) ×103,(1.4 ±0.51) ×103 and (1.88 ±1.41) ×103 min;AUC0-∞(5.87 ±1.39) ×103,(4.53 ±1.11) ×103 and (3.91 ±2.12) ×103 mg/(L· min),respectively.Conclusion:The data obtained in our findings may supply valuable experimental parameters for the coming clinical application of corn PIC .