皖南医学院学报
皖南醫學院學報
환남의학원학보
ACTA ACADEMIAE MEDICINAE WANNAN
2014年
1期
5-8
,共4页
郭呈林%方朝晖%江婷%杨慧
郭呈林%方朝暉%江婷%楊慧
곽정림%방조휘%강정%양혜
糖尿病肾病%丹蛭降糖胶囊%血糖%糖化血红蛋白%24h尿蛋白量
糖尿病腎病%丹蛭降糖膠囊%血糖%糖化血紅蛋白%24h尿蛋白量
당뇨병신병%단질강당효낭%혈당%당화혈홍단백%24h뇨단백량
diatetic nephropathy%Danzhi Jiangtang capsule%blood sugar%glycated hemoglobin%24-hour urine protein level
目的：观察益气养阴活血方丹蛭降糖胶囊对糖尿病肾病大鼠的治疗作用。方法：SD大鼠单侧肾脏结扎后链脲佐菌素腹腔注射制造糖尿病肾病大鼠模型，分为假手术组、模型对照组、益气养阴活血方（丹蛭降糖胶囊）低、中、高剂量组，分别给药6周后观察糖尿病肾病大鼠一般情况及血糖、糖化血红蛋白、尿量、24 h尿蛋白量。结果：模型大鼠给药前造模动物血糖、糖化血红蛋白、尿量、24 h尿蛋白量显著升高，给药6周后均能不同程度降低各指标。结论：益气养阴活血方（丹蛭降糖胶囊）可降低糖尿病肾病大鼠的血糖，改善糖尿病肾病大鼠肾功能，对糖尿病肾病有一定的治疗作用，为临床使用提供依据。
目的：觀察益氣養陰活血方丹蛭降糖膠囊對糖尿病腎病大鼠的治療作用。方法：SD大鼠單側腎髒結扎後鏈脲佐菌素腹腔註射製造糖尿病腎病大鼠模型，分為假手術組、模型對照組、益氣養陰活血方（丹蛭降糖膠囊）低、中、高劑量組，分彆給藥6週後觀察糖尿病腎病大鼠一般情況及血糖、糖化血紅蛋白、尿量、24 h尿蛋白量。結果：模型大鼠給藥前造模動物血糖、糖化血紅蛋白、尿量、24 h尿蛋白量顯著升高，給藥6週後均能不同程度降低各指標。結論：益氣養陰活血方（丹蛭降糖膠囊）可降低糖尿病腎病大鼠的血糖，改善糖尿病腎病大鼠腎功能，對糖尿病腎病有一定的治療作用，為臨床使用提供依據。
목적：관찰익기양음활혈방단질강당효낭대당뇨병신병대서적치료작용。방법：SD대서단측신장결찰후련뇨좌균소복강주사제조당뇨병신병대서모형，분위가수술조、모형대조조、익기양음활혈방（단질강당효낭）저、중、고제량조，분별급약6주후관찰당뇨병신병대서일반정황급혈당、당화혈홍단백、뇨량、24 h뇨단백량。결과：모형대서급약전조모동물혈당、당화혈홍단백、뇨량、24 h뇨단백량현저승고，급약6주후균능불동정도강저각지표。결론：익기양음활혈방（단질강당효낭）가강저당뇨병신병대서적혈당，개선당뇨병신병대서신공능，대당뇨병신병유일정적치료작용，위림상사용제공의거。
Objective:To observe the therapeutic effects of Danzhi Jiangtang capsule on rats with diabetic nephropathy ( DN) on Yiqi Yangyin Huoxue ( YYH) principle basis.Methods:DN rat( Sprague Dawley rats) models were initially developed by intraperitoneal injection of streptozotocin after ligation of unilateral kidney,and divided into sham operation group,model control group and groups treated with Danzhi Jiangtang capsule in low,medium and high dose.After consecutive 6-week intervention,all DN rats were observed regarding the general vital energy and level changes of blood sugar ,glycosylated hemoglobin,urinary production and 24-hour urine protein.Results:Elevated levels of blood sugar,glycosylated hemoglobin,urinary volume and 24-hour urine protein were found in the model rats before medication ,and the previous biochemical indicators were down-regulated to a certain extent after Danzhi Jiangtang capsule intervention.Conclusion:Danzhi Jiangtang capsule can effectively reduce the levels of blood sugar and improve the symptoms of DN rats on YYH recipe basis,suggesting that this regimen has certain therapeutic effect on DN and may be used in clinic .
