CAJ | 학술논문

尼克酰胺磷酸核糖转移酶（ Nicotinamide phosphoribosyl transferase ，Nampt）是哺乳动物细胞NAD补救合成途径的限速酶，涉及到细胞的能量代谢和增殖。近年来研究表明，Nampt与多种恶性肿瘤相关，它具有调节能量代谢和基因组不稳定性，促进肿瘤增殖和血管生成，促进肿瘤炎性反应和逃避免疫的功能。最新研究显示，Nampt在胶质瘤中高表达，并且与胶质瘤的增殖、迁移、侵袭和预后密切相关，可能为胶质瘤的研究和治疗提供新的靶点。
니극선알린산핵당전이매（ Nicotinamide phosphoribosyl transferase ，Nampt）시포유동물세포NAD보구합성도경적한속매，섭급도세포적능량대사화증식。근년래연구표명，Nampt여다충악성종류상관，타구유조절능량대사화기인조불은정성，촉진종류증식화혈관생성，촉진종류염성반응화도피면역적공능。최신연구현시，Nampt재효질류중고표체，병차여효질류적증식、천이、침습화예후밀절상관，가능위효질류적연구화치료제공신적파점。
Nampt is a rate -limiting enzyme in the mammalian salvaging pathway for the synthesis of NAD that is involved in cell metabolism and proliferation .In recent years,growing research has elucidated that Nampt is correlated to various malignant tumors .It has a complex functions including regulation of energy metabo-lism and genome instability,promotion of proliferation and angiogenesis ,tumor-promoting inflammation and a-voidance of immune destruction .Recent reports indicate that Nampt is highly expressed in gliomas ,and it is close-ly related to the proliferation ,migration,invasion and prognosis of gliomas ,which will provide a new target for the glioma research and therapy .