CAJ | 학술논문

胰岛素样生长因子结合蛋白-2（Insulin like growth factor binding protein -2，IGFBP-2）作为肺癌高敏感的生物标记物，在肺癌的发生、发展及治疗中扮演重要的角色。研究显示其通过激活IGF1R及整合素介导的信号转导通路促进肿瘤的进展；且目前发现其在肺癌的靶向治疗中也起着重要的作用，有望成为肺癌治疗的新靶点，因此本文就IGFBP-2与肺癌的关系进行总结及综述。
이도소양생장인자결합단백-2（Insulin like growth factor binding protein -2，IGFBP-2）작위폐암고민감적생물표기물，재폐암적발생、발전급치료중분연중요적각색。연구현시기통과격활IGF1R급정합소개도적신호전도통로촉진종류적진전；차목전발현기재폐암적파향치료중야기착중요적작용，유망성위폐암치료적신파점，인차본문취IGFBP-2여폐암적관계진행총결급종술。
As a high sensitive biomarker of lung cancer ,IGFBP2 plays an important role in the occur-rence,development and treatment of lung cancer .Studies have showed that it promotes tumor progression by acti-vating the IGF1R and integrin mediated signal transduction pathway .Recent researches have demonstrated that it participates in targeted therapy of lung cancer ,which may become a new target for the treatment of lung cancer . This paper makes a review on the relationship between IGFBP 2 and lung cancer .