实用肿瘤学杂志
實用腫瘤學雜誌
실용종류학잡지
JOURNAL OF PRACTICAL ONCOLOGY
2014年
1期
44-48
,共5页
侯军君%任立瑾%高媛媛%刘潇莲%蔡莉
侯軍君%任立瑾%高媛媛%劉瀟蓮%蔡莉
후군군%임립근%고원원%류소련%채리
乳腺癌%癌胚抗原%CA153%ROC曲线
乳腺癌%癌胚抗原%CA153%ROC麯線
유선암%암배항원%CA153%ROC곡선
Breast cancer%Carcinoembryonic antigen%Cancer antigen 153%ROC curves
目的：用ROC曲线评价CEA及CA153监测HER-2阳性乳腺癌患者术后复发转移的价值，并确立诊断HER-2阳性乳腺癌患者术后复发转移的最佳临界值。方法收集127例HER-2阳性乳腺癌患者CEA及CA153数值，将其分为复发转移及未复发转移两组。绘制ROC曲线，找到最佳临界值，同时比较最佳临界值与常规诊断值诊断复发转移的优劣。结果复发转移组较未复发转移组CEA及CA153水平显著偏高（P＜0．0001），CEA、CA153诊断复发转移ROC曲线下面积分别为0．752、0．820，对应的最佳临界值分别为3．5 ng/mL、17．89 U/mL。 CEA和CA153最佳临界值敏感性分别为46．15％、65．38％，CEA和CA153最佳临界值特异性分别为97．33％、89．33％。结论 CEA、CA153在HER-2阳性乳腺癌患者术后判断复发转移中具有中等价值，诊断术后复发转移的最佳临界值分别为3．5 ng/mL、17．89 U/mL。
目的：用ROC麯線評價CEA及CA153鑑測HER-2暘性乳腺癌患者術後複髮轉移的價值，併確立診斷HER-2暘性乳腺癌患者術後複髮轉移的最佳臨界值。方法收集127例HER-2暘性乳腺癌患者CEA及CA153數值，將其分為複髮轉移及未複髮轉移兩組。繪製ROC麯線，找到最佳臨界值，同時比較最佳臨界值與常規診斷值診斷複髮轉移的優劣。結果複髮轉移組較未複髮轉移組CEA及CA153水平顯著偏高（P＜0．0001），CEA、CA153診斷複髮轉移ROC麯線下麵積分彆為0．752、0．820，對應的最佳臨界值分彆為3．5 ng/mL、17．89 U/mL。 CEA和CA153最佳臨界值敏感性分彆為46．15％、65．38％，CEA和CA153最佳臨界值特異性分彆為97．33％、89．33％。結論 CEA、CA153在HER-2暘性乳腺癌患者術後判斷複髮轉移中具有中等價值，診斷術後複髮轉移的最佳臨界值分彆為3．5 ng/mL、17．89 U/mL。
목적：용ROC곡선평개CEA급CA153감측HER-2양성유선암환자술후복발전이적개치，병학립진단HER-2양성유선암환자술후복발전이적최가림계치。방법수집127례HER-2양성유선암환자CEA급CA153수치，장기분위복발전이급미복발전이량조。회제ROC곡선，조도최가림계치，동시비교최가림계치여상규진단치진단복발전이적우렬。결과복발전이조교미복발전이조CEA급CA153수평현저편고（P＜0．0001），CEA、CA153진단복발전이ROC곡선하면적분별위0．752、0．820，대응적최가림계치분별위3．5 ng/mL、17．89 U/mL。 CEA화CA153최가림계치민감성분별위46．15％、65．38％，CEA화CA153최가림계치특이성분별위97．33％、89．33％。결론 CEA、CA153재HER-2양성유선암환자술후판단복발전이중구유중등개치，진단술후복발전이적최가림계치분별위3．5 ng/mL、17．89 U/mL。
Objective To explore the value of carcinoembryonic antigen ( CEA) and cancer antigen 153 ( CA153 ) in detecting tumor recurrences and to establish the optimal operating point of diagnosis of recurrences in HER-2 overexpressing breast cancer using ROC curves .Methods A total of 127 HER -2 overexpressing breast cancer patients was enrolled into this study and subdivided into two groups ,the recurrence group and the non-recurrence group .We created a ROC curve and found out the optimal operating point .Then we compared the advantage of detecting recurrences between optimal operating point in the ROC curve and the diagnostic point that we usually used .Results The recurrence groups showed significantly higher CEA and CA 153 levels than the non-recurrence groups(P<0.0001).The area under the curve(AUC)of the CEA and CA153 were 0.752 and 0.820 respectively and the optimal operating point were 3.5 ng/mL and 17.89 U/mL,respectively.The sensitivi-ties of the optimal operating point of CEA and CA 153 were 46.15%and 65.38%respectively,and the specifici-ties were 97.33%and 89.33%, respectively.Conclusion CEA and CA153 process medium value for detecting recurrences in HER-2 overexpressing breast cancer .
