CAJ | 학술논문

目的：探讨三阴性乳腺癌（ TNBC）中基质金属蛋白酶-9（ MMP-9）及E-钙粘蛋白（ E-cadherin）表达情况及二者与TNBC临床病理特征的关系，从而分析MMP-9与E-cadherin在TNBC发生发展中的作用。方法应用免疫组化法检测127例TNBC组织中MMP-9和E-cadherin的表达情况。结果 TNBC中MMP-9阳性表达率为53．54％，E-cadherin阳性表达率为32．28％。 MMP-9的表达与肿瘤大小（P＝0．007），组织学分级（P＝0．006），临床分期（P＝0．003），淋巴结转移（P＝0．000）和淋巴管浸润（P＝0．015）相关。 E-cadherin的表达与淋巴结转移（P＝0．016）和淋巴管浸润（P＝0．021）相关。同时统计结果显示二者表达与其他因素无相关性（ P＞0．05）。结论 MMP-9和E-cadherin与TNBC的浸润和转移有关，可能成为TNBC靶向治疗的研究靶点。
목적：탐토삼음성유선암（ TNBC）중기질금속단백매-9（ MMP-9）급E-개점단백（ E-cadherin）표체정황급이자여TNBC림상병리특정적관계，종이분석MMP-9여E-cadherin재TNBC발생발전중적작용。방법응용면역조화법검측127례TNBC조직중MMP-9화E-cadherin적표체정황。결과 TNBC중MMP-9양성표체솔위53．54％，E-cadherin양성표체솔위32．28％。 MMP-9적표체여종류대소（P＝0．007），조직학분급（P＝0．006），림상분기（P＝0．003），림파결전이（P＝0．000）화림파관침윤（P＝0．015）상관。 E-cadherin적표체여림파결전이（P＝0．016）화림파관침윤（P＝0．021）상관。동시통계결과현시이자표체여기타인소무상관성（ P＞0．05）。결론 MMP-9화E-cadherin여TNBC적침윤화전이유관，가능성위TNBC파향치료적연구파점。
Objective To investigate the expression of matrixmetalloprotein -9(MMP-9)and E-cad-herin in triple negative breast cancer ( TNBC) and its relationship with the clinicopathologic features of TNBC .To analyze the function of MMP -9 and E-cadherin in TNBC .Methods Immunohistochemical method was used to detect the expression of MMP -9 and E-cadherin in 127 cases of TNBC.Results The MMP-9 positive rate was 53.54%and E-cadherin positive grade was 32.28%in TNBC.Expression of MMP-9 was correlated with tumor size(P=0.007),histological grade(P=0.006),TNM stage(P=0.003),lymph node metastasis(P=0.000)and lymph duct invasive(P=0.000).Expression of E-cadherin was correlated with lymph node metasta-sis(P=0.016)and lymph duct invasive(P=0.015).However,they were not correlated with other factors .Con-clusion The expression of MMP -9 and E -cadherin was correlated with invasion and metastasis in TNBC , which could be an important research topic in the future studies .