CAJ | 학술논문

人源化小鼠从起初的人-鼠嵌合体到目前具有人体免疫活性的模型不断演进，已用于人免疫缺陷病毒、EB病毒、丙型肝炎病毒和登革病毒等病原体的感染、发病机制和防治的研究，取得了很大进展。我们简要介绍几种有代表性的人源化小鼠模型及其在病毒研究中的应用。
인원화소서종기초적인-서감합체도목전구유인체면역활성적모형불단연진，이용우인면역결함병독、EB병독、병형간염병독화등혁병독등병원체적감염、발병궤제화방치적연구，취득료흔대진전。아문간요개소궤충유대표성적인원화소서모형급기재병독연구중적응용。
From the original human-mouse chimeras to current human immunocompetent humanized mouse mod-els, great progress have been made in the creation and exploitation of hu-mice. Hu-mice have been used for re-search in the infection, pathogenesis, prophylactic and therapeutic approaches of some pathogens such as HIV, EBV, HCV and dengue virus. This review focused on several typical humanized mouse models and application in virus research.