CAJ | 학술논문

毒素战剂是重要的生物战剂之一，其最大的威胁来自它的高毒性和缺乏有效的防治手段。在毒素战剂中，肉毒毒素、志贺毒素、蓖麻毒素、相思子毒素等属于致死性生物战剂，葡萄球菌肠毒素B属于失能性生物战剂。生防疫苗作为毒素战剂的一种重要的有效预防手段，一直备受关注，但目前绝大部分毒素战剂的疫苗都还在研制中，随着分子生物学技术的快速发展，几种重要毒素战剂的重组疫苗研究已获得重要突破。我们重点介绍肉毒毒素、志贺毒素、蓖麻毒素、相思子毒素、葡萄球菌肠毒素B等毒素战剂生防疫苗的研究与发展。
독소전제시중요적생물전제지일，기최대적위협래자타적고독성화결핍유효적방치수단。재독소전제중，육독독소、지하독소、비마독소、상사자독소등속우치사성생물전제，포도구균장독소B속우실능성생물전제。생방역묘작위독소전제적일충중요적유효예방수단，일직비수관주，단목전절대부분독소전제적역묘도환재연제중，수착분자생물학기술적쾌속발전，궤충중요독소전제적중조역묘연구이획득중요돌파。아문중점개소육독독소、지하독소、비마독소、상사자독소、포도구균장독소B등독소전제생방역묘적연구여발전。
Toxin warfare agents are one of the important biological warfare agents, the biggest threat comes from their high toxicity and lack of effective means of prevention and treatment. The toxin warfare agents, for ex-ample, botulinum toxin, Shiga toxin, ricin and abrin, are lethal biological warfare agents, staphylococcal enterotoxin B belongs to incapacitating biological warfare agents. Biodefense vaccines as an important means of prevention of toxin warfare agents, have always been concerned, but most of them are under development, few have been privi-leged to use in clinic. In the early time, toxoid vaccines are difficult to use in humans because of their security problems. With the development of molecular biology techniques, the genetically engineered vaccine research has become more mature, in addition, DNA vaccine which is also a new direction has been studied in recent years. This article summarized botulinum toxin, Shiga toxin, ricin, abrin, staphylococcal enterotoxin B, 5 kinds of the im-portant toxin warfare agents' biodefense vaccine research and development.