中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
11期
1622-1624
,共3页
加替沙星%左氧氟沙星%细菌性%感染
加替沙星%左氧氟沙星%細菌性%感染
가체사성%좌양불사성%세균성%감염
Gatifloxacin%Levofloxacin%Bacteria%Infection
目的 比较加替沙星与左氧氟沙星治疗急性细菌感染的疗效,评价加替沙星治疗急性细菌感染的有效性和安全性.方法 将呼吸系统和泌尿系统感染的患者228例根据数字表法随机分为A组和B组,每组114例.A组给予加替沙星200 mg加入5％葡萄糖注射液100 ml静脉滴注；B组给予左氧氟沙星200 mg加入5％葡萄糖注射液100 ml静脉滴注.两组均予2次/d,疗程均为7～14 d.观察两组疗效和细菌清除率以及不良反应.结果 A组痊愈率、总有效率分别为68.4％、93.0％,B组分别为66.7％、90.3％,差异均无统计学意义(x2=0.184、0.213,均P＞0.05).A组细菌清除率、细菌药物敏感试验敏感率分别为89.4％、78.8％,B组分别为77.2％、70.3％,差异均有统计学意义(x2=4.812、4.236,均P＜0.05).A组不良反应发生率为7.0％,B组为6.1％,差异无统计学意义(x2=0.672,P＞0.05).结论 加替沙星治疗急性细菌引起的呼吸系统、泌尿系统感染疗效显著,不良反应较低,治疗效果与左氧氟沙星无明显差异,值得临床推广应用.
目的 比較加替沙星與左氧氟沙星治療急性細菌感染的療效,評價加替沙星治療急性細菌感染的有效性和安全性.方法 將呼吸繫統和泌尿繫統感染的患者228例根據數字錶法隨機分為A組和B組,每組114例.A組給予加替沙星200 mg加入5％葡萄糖註射液100 ml靜脈滴註；B組給予左氧氟沙星200 mg加入5％葡萄糖註射液100 ml靜脈滴註.兩組均予2次/d,療程均為7～14 d.觀察兩組療效和細菌清除率以及不良反應.結果 A組痊愈率、總有效率分彆為68.4％、93.0％,B組分彆為66.7％、90.3％,差異均無統計學意義(x2=0.184、0.213,均P＞0.05).A組細菌清除率、細菌藥物敏感試驗敏感率分彆為89.4％、78.8％,B組分彆為77.2％、70.3％,差異均有統計學意義(x2=4.812、4.236,均P＜0.05).A組不良反應髮生率為7.0％,B組為6.1％,差異無統計學意義(x2=0.672,P＞0.05).結論 加替沙星治療急性細菌引起的呼吸繫統、泌尿繫統感染療效顯著,不良反應較低,治療效果與左氧氟沙星無明顯差異,值得臨床推廣應用.
목적 비교가체사성여좌양불사성치료급성세균감염적료효,평개가체사성치료급성세균감염적유효성화안전성.방법 장호흡계통화비뇨계통감염적환자228례근거수자표법수궤분위A조화B조,매조114례.A조급여가체사성200 mg가입5％포도당주사액100 ml정맥적주；B조급여좌양불사성200 mg가입5％포도당주사액100 ml정맥적주.량조균여2차/d,료정균위7～14 d.관찰량조료효화세균청제솔이급불량반응.결과 A조전유솔、총유효솔분별위68.4％、93.0％,B조분별위66.7％、90.3％,차이균무통계학의의(x2=0.184、0.213,균P＞0.05).A조세균청제솔、세균약물민감시험민감솔분별위89.4％、78.8％,B조분별위77.2％、70.3％,차이균유통계학의의(x2=4.812、4.236,균P＜0.05).A조불량반응발생솔위7.0％,B조위6.1％,차이무통계학의의(x2=0.672,P＞0.05).결론 가체사성치료급성세균인기적호흡계통、비뇨계통감염료효현저,불량반응교저,치료효과여좌양불사성무명현차이,치득림상추엄응용.
Objective To compare the effect of gatifloxacin and levofloxacin for treating acute bacterial infection.Methods According to the digital table,228 patients with respiratory or urinary tract infections were randomly divided into group A and group B,114 cases in each group.Group A was given gatifloxacin 200mg,adding 5％ glucose injection 100ml intravenous drip injection twice daily; Group B was treated with levofloxacin 200mg,by adding 5％ glucose injection 100ml intravenous infusion twice daily.The treatment course lasted 7-14 days.The clincal effect,bacterial clearance rate and adverse reactions of the two groups were observed.Results The cure rate and total effective rate of group A was 68.4％,93.0％,respectively,which of group B was 66.7％,90.3％,respectively,the differences were statistically significant (x2 =0.184,0.213,all P ＞0.05).The bacterial clearance rate and bacterial drug sensitivity test sensitivity was 89.4％,78.8％,respectively,which of group B was 77.2％,70.3 ％,respectively,the differences were all statistically significant (x2 =4.812,4.236,all P ＜ 0.05).The incidence rate of adverse reactions of group A was 7.0％,which of group B was 6.1％,there was no statistically significant difference (x2 =0.672,P ＞0.05).Conclusion Gatifloxacin has better effect and lower adverse reactions in the treatment of acute bacterial respiratory or urinary tract infections,and there is no significant difference compared with levofloxacin treatment,and it is worthy of clinical application.
