CAJ | 학술논문

目的：探讨硼替佐米+阿霉素+地塞米松（PAD）化疗方案治疗多发性骨髓瘤（MM）的临床疗效和安全性．方法选取红河州第一人民医院收治的38例多发性骨髓瘤患者，随机将其分为观察组和对照组各19例．观察组采用硼替佐米+阿霉素+地塞米松（PAD）方案进行化疗，对照组采用VAD方案（长春新碱+阿霉素+地塞米松）进行化疗，对比2组患者的临床疗效和不良反应发生的情况．结果观察组的显效率为52.63%，显著高于对照组（＜0.05）；观察组的总有效率为78.95%，高于对照组（＜0.05；2组患者治疗过程中的不良反应事件的发生率对比，差异无统计学意义（＞0.05）．结论硼替佐米+阿霉素+地塞米松（PAD）化疗方案可提高多发性骨髓瘤的临床疗效，且不良反应可以耐受，安全性良好，值得在临床上推广应用．
목적：탐토붕체좌미+아매소+지새미송（PAD）화료방안치료다발성골수류（MM）적림상료효화안전성．방법선취홍하주제일인민의원수치적38례다발성골수류환자，수궤장기분위관찰조화대조조각19례．관찰조채용붕체좌미+아매소+지새미송（PAD）방안진행화료，대조조채용VAD방안（장춘신감+아매소+지새미송）진행화료，대비2조환자적림상료효화불량반응발생적정황．결과관찰조적현효솔위52.63%，현저고우대조조（＜0.05）；관찰조적총유효솔위78.95%，고우대조조（＜0.05；2조환자치료과정중적불량반응사건적발생솔대비，차이무통계학의의（＞0.05）．결론붕체좌미+아매소+지새미송（PAD）화료방안가제고다발성골수류적림상료효，차불량반응가이내수，안전성량호，치득재림상상추엄응용．
Objective The purpose of this study was to investigate the efficacy and safety of bortezomib +doxorubicin + dexamethasone (PAD) regimen in the treatment of patients with multiple myeloma (MM) . Methods Thirty-eight patients with MM in our hospital were selected and randomly divided into observation group and control group with 19 cases in each. The observation group was treated with PAD regimen and the control group was treated with VAD regimen (vincristine+doxorubicin+dexamethasone) . Clinical efficacy and adverse reaction were compared between the two groups. Results The effective rate and total effective rate of the observation group were 52.63%and 78.95%respectively, which were significantly higher than those of the control group ( <0.05 and <0.05) . There was no statistical difference in the incidence of adverse events between the two groups ( >0.05) . Conclusion PAD regimen could improve the clinical effect of treating patients with MM, and the adverse reactions can be tolerated. It is safe and worthy of clinical application.