CAJ | 학술논문

目的：研究宣威与非宣威地区非小细胞肺癌P63蛋白的表达，探讨其与生物学行为的关系．方法免疫组织化学法．结果 P63在肺鳞癌组织中高表达；非小细胞肺癌中，P63的表达与患者的TNM分期、组织分化程度及淋巴结转移情况有关，与患者性别无关；P63在非小细胞肺癌中在相同病理类型、分期、组织分化、淋巴结转移情况及相同性别的阳性表达率，宣威组与非宣威组比较，差异无统计学意义（＞0.05）．结论 P63的表达在宣威并无地区特异性，并不是宣威肺癌高发的原因.
목적：연구선위여비선위지구비소세포폐암P63단백적표체，탐토기여생물학행위적관계．방법면역조직화학법．결과 P63재폐린암조직중고표체；비소세포폐암중，P63적표체여환자적TNM분기、조직분화정도급림파결전이정황유관，여환자성별무관；P63재비소세포폐암중재상동병리류형、분기、조직분화、림파결전이정황급상동성별적양성표체솔，선위조여비선위조비교，차이무통계학의의（＞0.05）．결론 P63적표체재선위병무지구특이성，병불시선위폐암고발적원인.
Objective The purpose of the study was to compare the P63 expression in non-small cell lung cancer (NSCLC) between Xuanwei and other regions, and to investigate the relationship of P63 expression and biological behavior. Methods Immunohistochemical method was used. Results The results indicated that the expression of P63 in lung squamous cell carcinoma was extraordinarily high. P63 was related to the TNM staging system,tissue differentiation degree and lymph node metastasis,but not related to gender. In NSCLC,there was no significant difference of the P63 positive expression rate in the same pathological types, staging, tissue differentiation degree, lymph node metastasis and gender between Xuanwei and other regions. It indicated that the expression of P63 was not the reason why it was high incidence of lung cancer in Xuanwei region.