CAJ | 학술논문

[目的]研究氟比洛芬酯超前镇痛对减少异丙酚复合瑞芬太尼全凭静脉麻醉术后疼痛及不良反应的效应。探讨氟比洛芬酯超前镇痛的给药方式、时间、剂量。[方法]选择期腹腔镜胆囊切除术患者40例，随机分为A、B两组，每组20例。A组切皮前静脉注射氟比洛芬酯100mg；B组气腹后即刻注射氟比洛芬酯100mg。双盲法观察患者术后2h（T1）、6h（T2）、24h（T3）的VAS评分。观察围拔管期的血压（BP）、心率（HR）、脉搏血氧饱和度（SpO2）以及躁动、呛咳、拔管后10min的Ramsay镇静评分情况。[结果]VAS评分于T1时A组低于B组（P＜0．05）。两组患者不良反应及拔管后Ramsay评分差异无统计学意义（P＞0．05）。[结论]氟比洛芬酯能有效缓解腹腔镜胆囊切除术后疼痛，手术前给药镇痛效果优于手术开始后给药，并能维持满意的镇静。
[목적]연구불비락분지초전진통대감소이병분복합서분태니전빙정맥마취술후동통급불량반응적효응。탐토불비락분지초전진통적급약방식、시간、제량。[방법]선택기복강경담낭절제술환자40례，수궤분위A、B량조，매조20례。A조절피전정맥주사불비락분지100mg；B조기복후즉각주사불비락분지100mg。쌍맹법관찰환자술후2h（T1）、6h（T2）、24h（T3）적VAS평분。관찰위발관기적혈압（BP）、심솔（HR）、맥박혈양포화도（SpO2）이급조동、창해、발관후10min적Ramsay진정평분정황。[결과]VAS평분우T1시A조저우B조（P＜0．05）。량조환자불량반응급발관후Ramsay평분차이무통계학의의（P＞0．05）。[결론]불비락분지능유효완해복강경담낭절제술후동통，수술전급약진통효과우우수술개시후급약，병능유지만의적진정。
[Objective] To study the efficacy of preemptive analgesia with flurbiprofen axetil on reducing postoperative pain and adverse reaction of propofol combined with remifentanil for total intravenous anesthesia , and to explore administration method ,time and dosage of preemptive analgesia with flurbiprofen axetil .[Meth-ods] Totally 40 patients undergoing laparoscopic cholecystectomy were chosen and randomly divided into group A( n=20) and group B( n =20) .Group A received intravenous flurbiprofen axetil 100mg before skin inci-sion ,while group B received intravenous flurbiprofen axetil 100mg immediately at pneumoperitoneum .Double blind method was used to observe VAS score 2h(T1 ) ,6h(T2 ) and 24h(T3 ) after operation .Blood pressure (BP) ,heart rate(HR) ,SpO2 ,agitation ,cough during the extubation and Ramsay sedation score 10min after extubation were observed .[Results]VAS scores in group A at T1 were lower than those in group B ( P <0 .05) .There was no significant difference in the incidence of adverse reaction and Ramsay score after extuba-tion between two groups( P > 0 .05) .[Conclusion] Flurbiprofen axetil can effectively relieve the pain after laparoscopic cholecystectomy .The analgesic efficacy of preoperative administration is better than postoperative administration .Preoperative administration can maintain satisfactory sedative effect .