CAJ | 학술논문

[目的]探讨原癌基因（c-Myc）和环氧合酶-2（COX-2）在年轻宫颈鳞癌（SCC）中的表达、微血管密度（MVD）及临床意义。[方法]选择年轻女性SCC组织标本40份、宫颈上皮内瘤变（CIN）标本31份，正常宫颈组织（NCE）10份，采用免疫组化SP法检测各组c-Myc、COX-2的表达水平和MVD ，分析其表达与肿瘤分期、病理分型、淋巴结转移等相关性。[结果]SCC中c-M yc 、COX-2的阳性表达率分别为62．5％（25/40）、67．5％（27/40），均显著高于 CIN 组和 NCE组（ P ＜0．01）；c-Myc表达与分化及淋巴结转移有关（ P ＜0．01），与分期无关；COX-2的表达与SCC的分期及淋巴结转移有相关性（ P ＜0．01）；NCE、CIN、SCC组中M VD呈逐渐升高趋势，在SCC组中c-M yc 、COX-2阳性表达和阴性表达的M VD值具有明显相关性（ P ＜0．01）；SCC组织中c-Myc 、COX-2表达呈正相关。[结论]c-Myc和COX-2在SCC发生、发展中起重要作用，两者在宫颈癌血管生成中有协调作用。
[목적]탐토원암기인（c-Myc）화배양합매-2（COX-2）재년경궁경린암（SCC）중적표체、미혈관밀도（MVD）급림상의의。[방법]선택년경녀성SCC조직표본40빈、궁경상피내류변（CIN）표본31빈，정상궁경조직（NCE）10빈，채용면역조화SP법검측각조c-Myc、COX-2적표체수평화MVD ，분석기표체여종류분기、병리분형、림파결전이등상관성。[결과]SCC중c-M yc 、COX-2적양성표체솔분별위62．5％（25/40）、67．5％（27/40），균현저고우 CIN 조화 NCE조（ P ＜0．01）；c-Myc표체여분화급림파결전이유관（ P ＜0．01），여분기무관；COX-2적표체여SCC적분기급림파결전이유상관성（ P ＜0．01）；NCE、CIN、SCC조중M VD정축점승고추세，재SCC조중c-M yc 、COX-2양성표체화음성표체적M VD치구유명현상관성（ P ＜0．01）；SCC조직중c-Myc 、COX-2표체정정상관。[결론]c-Myc화COX-2재SCC발생、발전중기중요작용，량자재궁경암혈관생성중유협조작용。
[Objective] To explore the expression of proto-oncogen gene c-Myc and cyclooxygenase-2 (COX-2) in young patients with squamous carcinoma of the cervix (SCC) ,microvessel density (MVD) and their significance .[Methods] The samples of 40 SCC tissues ,31 cervical intraepithelial neoplasia(CIN) and 10 normal cervical tissues (NCE) were collected .Immunohistochemical SP method was used to detect the expres-sions of COX-2 ,c-Myc and microvessel density (MVD) .The correlation of the expression with tumor stage , pathological type and lymph node metastasis was analyzed .[Results] The positive expression rates of c-Myc and COX-2 in SCC were 62 .5% (25/40) and 67 .5% (27/40) respectively ,which were significantly higher than those in CIN group and NCE group( P<0 .01) .The expression of c-Myc was related to the differentiation and lymph node metastasis( P <0 .01) ,but not related to the staging .The expression of COX-2 had the correla-tion with the staging and lymph node metastasis of SCC ( P < 0 .01) .MVD in NCE ,CIN and SCC groups showed a trend of rising .The positive and negative expression of c-Myc and COX-2 in SCC group had obvious correlation with MVD( P<0 .01) .The expression of c-Myc in SCC group was positively related to the expres-sion of COX-2 .[Conclusion]COX-2 and c-Myc play an important role in the occurrence and development of SCC .Both of them have synergistic effect in the angiogenesis of cervical cancer .