CAJ | 학술논문

[目的]探讨前列腺癌患者精浆和血清中抑癌因子 H-rev107和T IG3的表达水平及其与前列腺特异性抗原（PSA）的相关性。[方法]ELISA 法检测前列腺癌患者（试验组）和健康男性（对照组）血清及精浆中 H-rev107、TIG3及PSA的表达水平。[结果]试验组血清中 H-rev107、TIG3及 PSA表达均高于对照组（均 P ＜0．05），H-rev107和TIG3分别与PSA在血清中的水平呈正相关。精浆中 H-rev107的表达试验组高于对照组（ P ＜0．05），但其TIG3和PSA表达两组间比较无统计学意义（ P ＞0．05）。[结论]抑癌因子 H-rev107和 TIG3均表达于前列腺癌的血清及精浆中，H-rev107在血清及精浆均有较高的表达，H-rev107和 TIG3分别与PSA在血清中的水平呈正相关。
[목적]탐토전렬선암환자정장화혈청중억암인자 H-rev107화T IG3적표체수평급기여전렬선특이성항원（PSA）적상관성。[방법]ELISA 법검측전렬선암환자（시험조）화건강남성（대조조）혈청급정장중 H-rev107、TIG3급PSA적표체수평。[결과]시험조혈청중 H-rev107、TIG3급 PSA표체균고우대조조（균 P ＜0．05），H-rev107화TIG3분별여PSA재혈청중적수평정정상관。정장중 H-rev107적표체시험조고우대조조（ P ＜0．05），단기TIG3화PSA표체량조간비교무통계학의의（ P ＞0．05）。[결론]억암인자 H-rev107화 TIG3균표체우전렬선암적혈청급정장중，H-rev107재혈청급정장균유교고적표체，H-rev107화 TIG3분별여PSA재혈청중적수평정정상관。
[Objective] To explore the expressions of tumor suppressors H-rev107 and TIG3 in seminal plasma and serum of patients with prostate carcinoma and their correlation with prostate-specific antigen(PSA) .[Methods] ELISA was used to detect the expression levels of H-rev107 ,TIG3 and PSA in serum and seminal plasma of patients with pros-tate carcinoma(experimental group) and healthy men (control group) .[Results] The expression levels of serum H-rev107 ,TIG3 and PSA in experimental group were higher than those in control group (all P<0 .05) .Serum levels of H-rev107 and TIG3 were positively correlated with PSA ,respectively .The expression of H-rev107 in seminal plasma of ex-perimental group was higher than that in control group ( P<0 .05) ,but there was no significant different in the expres-sion of TIG3 and PSA between two groups( P >0 .05) .[Conclusion] Tumor suppressors H-rev107 and TIG3 are ex-pressed in serum and seminal plasma of prostate cancer .H-rev107 and TIG3 in serum are positively correlated with PSA , respectively .