CAJ | 학술논문

目的：观察急性冠脉综合征（ ACS）行经皮冠状动脉介入治疗（ PCI）术的患者经瑞舒伐他汀降脂治疗后颈动脉斑块逆转程度与术后主要不良心血管事件（ MACE ）发生率之间的关系。方法180例急性冠脉综合征患者，予PCI术治疗，术前0～3 d开始服用瑞舒伐他汀10 mg/d，围术期（手术前后3 d内）、术后6个月、12个月分别行颈动脉多普勒超声检查，按照颈动脉粥样斑块减轻的程度分为明显逆转组和无明显逆转组，随访12个月，比较2组患者MACE的发生率。结果明显逆转组患者MACE发生率低于无明显逆转组患者（随访6个月时10．2％ vs．22．8％， P ＜0．05；随访12个月时17．6％vs 43．6％， P ＜0．01）。结论瑞舒伐他汀逆转颈动脉斑块程度不一，有明显逆转的ACS患者PCI术后近期预后较好。
목적：관찰급성관맥종합정（ ACS）행경피관상동맥개입치료（ PCI）술적환자경서서벌타정강지치료후경동맥반괴역전정도여술후주요불양심혈관사건（ MACE ）발생솔지간적관계。방법180례급성관맥종합정환자，여PCI술치료，술전0～3 d개시복용서서벌타정10 mg/d，위술기（수술전후3 d내）、술후6개월、12개월분별행경동맥다보륵초성검사，안조경동맥죽양반괴감경적정도분위명현역전조화무명현역전조，수방12개월，비교2조환자MACE적발생솔。결과명현역전조환자MACE발생솔저우무명현역전조환자（수방6개월시10．2％ vs．22．8％， P ＜0．05；수방12개월시17．6％vs 43．6％， P ＜0．01）。결론서서벌타정역전경동맥반괴정도불일，유명현역전적ACS환자PCI술후근기예후교호。
Objective To observe the effect of rosuvastatin on arteriosclerosis plaque of carotid artery in patients with acute coronary syndrome ( ACS ) who underwent percutaneous coronary intervention ( PCI ) and to explore the relationship between carotid plaques reversal degree and the incidence of major adverse cardiac events (MACE) after PCI.Methods A total of 180 patients with ACS (109 males and 71 females,age range:38~77yr) were treated with rosuvastatin (10mg,0~3 days before and after PCI ) .The area of carotid artery plaques was measured by carotid Doppler ultrasound at perioperative period (3 days before and after PCI ),6 months and 12 months after PCI,then the patients were divided into two groups according to the alleviative degree of carotid atherosclerosis plaques:group A ( obvious reversal group ) and group B ( no obvious reversal group ) , the patients in both groups were followed up for 12 months and the incidences of MACE were compared between the two groups .Results The incidences of MACE in group A were significantly lower than those in group B (10.2%vs 22.8% in 6 months after PCI and 17.6% vs 43.6% in 12 months after PCI, P <0.01).Conclusion The rosuvastatin can reverse carotid atherosclerosis plaques at different degrees ,the patients with obvious carotid plaques reversal have better short-term prognoses after PCI .