河北医药
河北醫藥
하북의약
HEBEI MEDICAL JOURNAL
2014年
8期
1135-1137
,共3页
沈琪%薛冰%丁东新%缪以颖%钟葛瑾
瀋琪%薛冰%丁東新%繆以穎%鐘葛瑾
침기%설빙%정동신%무이영%종갈근
糖尿病肾病%老年人%炎性因子%血清肿瘤坏死因子%白介素-6%C-反应蛋白
糖尿病腎病%老年人%炎性因子%血清腫瘤壞死因子%白介素-6%C-反應蛋白
당뇨병신병%노년인%염성인자%혈청종류배사인자%백개소-6%C-반응단백
diabetic nephropathy%the elderly%inflammation factors%serum tumor necrosis factor-α%interleukin-6%C-reactive protein
目的：探讨老年糖尿病肾病与炎症因子的关系。方法选择老年科门诊及住院的老年2型糖尿病患者96例，根据尿白蛋白排泄率分为3组：正常蛋白尿组19例， UAER ＜20μg/min；微量蛋白尿组， UAER 20～200μg/min；临床蛋白尿组，UAER＞200μg/min。抽取空腹静脉血，分别测定3组患者血清TNF-α、IL-6、C-RP的含量，用放射免疫分析测定血清肿瘤坏死因子、白介素-6（IL-6）的含量，用透射比浊法测定C反应蛋白（RP）。结果3组血清TNF-α、IL-6、CRP的含量有显著差异（ P ＜0．05），微量蛋白尿组和临床蛋白尿组的血清TNF-α、IL-6、CRP的含量明显高于正常蛋白尿组（ P ＜0．05），并随着糖尿病肾病程度的加重而逐步升高。结论炎性反应可能参与了糖尿病肾病的发生发展，对炎性因子的监测有益于老年糖尿病肾病的诊治。
目的：探討老年糖尿病腎病與炎癥因子的關繫。方法選擇老年科門診及住院的老年2型糖尿病患者96例，根據尿白蛋白排洩率分為3組：正常蛋白尿組19例， UAER ＜20μg/min；微量蛋白尿組， UAER 20～200μg/min；臨床蛋白尿組，UAER＞200μg/min。抽取空腹靜脈血，分彆測定3組患者血清TNF-α、IL-6、C-RP的含量，用放射免疫分析測定血清腫瘤壞死因子、白介素-6（IL-6）的含量，用透射比濁法測定C反應蛋白（RP）。結果3組血清TNF-α、IL-6、CRP的含量有顯著差異（ P ＜0．05），微量蛋白尿組和臨床蛋白尿組的血清TNF-α、IL-6、CRP的含量明顯高于正常蛋白尿組（ P ＜0．05），併隨著糖尿病腎病程度的加重而逐步升高。結論炎性反應可能參與瞭糖尿病腎病的髮生髮展，對炎性因子的鑑測有益于老年糖尿病腎病的診治。
목적：탐토노년당뇨병신병여염증인자적관계。방법선택노년과문진급주원적노년2형당뇨병환자96례，근거뇨백단백배설솔분위3조：정상단백뇨조19례， UAER ＜20μg/min；미량단백뇨조， UAER 20～200μg/min；림상단백뇨조，UAER＞200μg/min。추취공복정맥혈，분별측정3조환자혈청TNF-α、IL-6、C-RP적함량，용방사면역분석측정혈청종류배사인자、백개소-6（IL-6）적함량，용투사비탁법측정C반응단백（RP）。결과3조혈청TNF-α、IL-6、CRP적함량유현저차이（ P ＜0．05），미량단백뇨조화림상단백뇨조적혈청TNF-α、IL-6、CRP적함량명현고우정상단백뇨조（ P ＜0．05），병수착당뇨병신병정도적가중이축보승고。결론염성반응가능삼여료당뇨병신병적발생발전，대염성인자적감측유익우노년당뇨병신병적진치。
Objective To explore the relationship between inflammation factors and diabetic nephropathy in elderly patients .Methods A total of 96 elderly patients with type 2 diabetes mellitus were enrolled in the study .All the patients were divided into three groups according to urinary albumin excretion rate: normal proteinuria group ( UAER <20μg/min ) , microalbuminuria group ( UAER20-200μg/min ) and clinical proteinuria group ( UAER >200μg/min ) .The fasting venous blood specimens of all the patients were taken out , then the serum levels of tumor necrosis factor-α( TNF-α) , interleukin-6 ( IL-6 ) were detected by radio-immunity assay and the serum levels of C-reactive protein ( CRP ) were detected by turbidimetry.Results There were significant differences in the serum levels of TNF-α,IL-6,CRP among the three groups .The serum levels of TNF-α,IL-6,CRP in microalbuminuria group and clinical proteinuria group were significantly higher than those in normal proteinuria group ( P <0.05),moreover,which increased with the aggravation of diabetic nephropathy degree . Conclusion Inflammation factors may be involved in the pathogenesis and development of diabetic nephropathy , and the detection of these inflammation factors is helpful for diagnosis and treatment of diabetic nephropathy in elderly patients .
