CAJ | 학술논문

为了研究热熔压敏胶基质结构对药物的释放性能的影响，实验中以不同牌号的苯乙烯-异戊二烯-苯乙烯嵌段聚合物为主体材料，制备了具有不同结构的压敏胶基质。同时选择了水杨酸甲酯、辣椒素、盐酸苯海拉明为模型药物，考察了药物在不同基质中的释放行为。研究结果表明，药物在基质中以分散或溶解状态分布，浓度为2%时无结晶析出。药物在基质中的扩散决定了药物的释放速率。对于不同药物，在基质中溶解度大，药物的扩散系数高，则释放速率快。对于同种药物在不同基质中的释放，软硬两相分布均匀的嵌段聚合物能够提供较多的自由体积，由其制备的基质具有较低的储能模量平台和较低的黏度，可以提高药物在基质中的扩散系数，导致释放速率加快。
위료연구열용압민효기질결구대약물적석방성능적영향，실험중이불동패호적분을희-이무이희-분을희감단취합물위주체재료，제비료구유불동결구적압민효기질。동시선택료수양산갑지、랄초소、염산분해랍명위모형약물，고찰료약물재불동기질중적석방행위。연구결과표명，약물재기질중이분산혹용해상태분포，농도위2%시무결정석출。약물재기질중적확산결정료약물적석방속솔。대우불동약물，재기질중용해도대，약물적확산계수고，칙석방속솔쾌。대우동충약물재불동기질중적석방，연경량상분포균균적감단취합물능구제공교다적자유체적，유기제비적기질구유교저적저능모량평태화교저적점도，가이제고약물재기질중적확산계수，도치석방속솔가쾌。
In order to investigate the effect of matrix structure on drug release profiles, hot-melt pressure sensitive adhesives were made with different styrene-isoprene-styrene block copolymers. Methyl salicylate, capsaicin, and diphenhydramine hydrochloride were selected as model drugs to perform the release experiment. The result shows that the drugs exist in a dispersed or dissolved state in the matrix and no crystallization occurs with the drug concentration up to 2%. The drug release profile is controlled by the diffusion mechanism in the matrix. The drug with high solubility in the matrix gives a high diffusion coefficient, and leads to have a fast release behaviors. On the other hand, the block copolymer with homogeneous and mesh-like microstructures possesses more free volume of intermolecular, which causes the reduction of the energy storage modulus and viscosity of the matrix and results in a higher diffusion rate of the drugs.