传染病信息
傳染病信息
전염병신식
INFECTIOUS DISEASE INFORMATION
2014年
1期
43-44
,共2页
阴茎头炎%氟康唑%念珠菌属
陰莖頭炎%氟康唑%唸珠菌屬
음경두염%불강서%념주균속
balanitis%fluconazole%Candida
目的：观察氟康唑联合布替萘芬乳膏治疗念珠菌性包皮龟头炎的临床疗效。方法80例念珠菌性包皮龟头炎患者随机分为对照组（单用布替萘芬）和治疗组（布替萘芬+氟康唑），每组40例。同时选择40例配偶以布替萘芬+氟康唑治疗，并观察疗效。入组对象以布替萘芬乳膏外涂（1次/d）或布替萘芬乳膏+氟康唑顿服（150 mg/d），连续用药14 d。所有患者分别于治疗前、治疗后第7天及第14天记录临床症状和体征，并做真菌镜检，以判断疗效。结果用药第7天时，对照组和治疗组总有效率分别为65%和70%，真菌清除率分别为60%和80%，差异无统计学意义（P均＞0.05）。用药第14天时，对照组和治疗组的总有效率分别为70%和95%（P＜0.05），真菌清除率分别为85%和90%（P＞0.05）。2组均无明显不良反应发生。配偶组总有效率为100%，真菌清除率为95%。结论氟康唑联合布替萘芬乳膏治疗念珠菌性包皮龟头炎安全有效。
目的：觀察氟康唑聯閤佈替萘芬乳膏治療唸珠菌性包皮龜頭炎的臨床療效。方法80例唸珠菌性包皮龜頭炎患者隨機分為對照組（單用佈替萘芬）和治療組（佈替萘芬+氟康唑），每組40例。同時選擇40例配偶以佈替萘芬+氟康唑治療，併觀察療效。入組對象以佈替萘芬乳膏外塗（1次/d）或佈替萘芬乳膏+氟康唑頓服（150 mg/d），連續用藥14 d。所有患者分彆于治療前、治療後第7天及第14天記錄臨床癥狀和體徵，併做真菌鏡檢，以判斷療效。結果用藥第7天時，對照組和治療組總有效率分彆為65%和70%，真菌清除率分彆為60%和80%，差異無統計學意義（P均＞0.05）。用藥第14天時，對照組和治療組的總有效率分彆為70%和95%（P＜0.05），真菌清除率分彆為85%和90%（P＞0.05）。2組均無明顯不良反應髮生。配偶組總有效率為100%，真菌清除率為95%。結論氟康唑聯閤佈替萘芬乳膏治療唸珠菌性包皮龜頭炎安全有效。
목적：관찰불강서연합포체내분유고치료념주균성포피구두염적림상료효。방법80례념주균성포피구두염환자수궤분위대조조（단용포체내분）화치료조（포체내분+불강서），매조40례。동시선택40례배우이포체내분+불강서치료，병관찰료효。입조대상이포체내분유고외도（1차/d）혹포체내분유고+불강서돈복（150 mg/d），련속용약14 d。소유환자분별우치료전、치료후제7천급제14천기록림상증상화체정，병주진균경검，이판단료효。결과용약제7천시，대조조화치료조총유효솔분별위65%화70%，진균청제솔분별위60%화80%，차이무통계학의의（P균＞0.05）。용약제14천시，대조조화치료조적총유효솔분별위70%화95%（P＜0.05），진균청제솔분별위85%화90%（P＞0.05）。2조균무명현불량반응발생。배우조총유효솔위100%，진균청제솔위95%。결론불강서연합포체내분유고치료념주균성포피구두염안전유효。
Objective To observe clinical effects of flucoanzole combined with butenafine cream in treatment of candidal balano-posthitis. Methods A total of 80 patients with candidal balanoposthitis were randomized into a control group (given butenafine cream only) and a treatment group (given butenafine cream plus fluconazole), with 40 patients in each group. Forty spouses (spouse group) were selected and given butenafine cream plus fluconazole. Butenafine cream was for external use one time per day, and flu-conazole was used orally 150 mg per day, for 14 days. The clinical signs and symptoms were recorded before treatment, and at the 7th and 14th day of treatment, respectively. Microscopic examination of fungi was performed for determining therapeutic effects. Results At the 7th day of treatment, the total effective rates of the control group and the treatment group were 65%and 70%, fungi clearance rates of the control group and the treatment group were 60% and 80%, respectively, and the differences were not signifi-cant between the two groups (P>0.05). At the 14th day of treatment, the total effective rates of the control group and the treatment group were 70% and 95%, and the difference was significant between the two groups (P<0.05); fungi clearance rates of the control group and the treatment group were 85%and 90%, respectively, and the difference was not significant between the two groups (P>0.05). No obvious adverse reactions were found in the control group and the treatment group . The total effective rate was 100% and fungal clearance rate was 95% in the spouse group. Conclusion Flucozanole combined with butenafine cream is safe and effec-tive in treatment of candidal balanoposthitis.
