CAJ | 학술논문

目的：探讨血浆N末端-脑钠肽前体(NT-proBNP)水平与不稳定型心绞痛(UAP)患者近期预后的关系。方法：因胸痛住院并经冠状动脉造影检查确诊为UAP的患者52例，分别检测症状发作后18h和症状缓解96h血浆NT-proBNP水平，并计算差值比。对UAP患者随访30天，记录患者主要心血管事件(MACE)的发生情况，并应用受试者工作曲线(ROC)分析差值比对UAP患者发生近期心血管事件的预测价值。结果：发生心血管事件患者的NT-proBNP差值比高于未发生者，差异具有统计学意义(P＜0.05)。ROC结果显示，NT-proBNP差值比为0.99时，其预测UAP患者近期发生心血管事件的灵敏度和特异度分别为64.3%和81.8%。结论：NT-proBNP差值比可用来预测UAP患者近期心血管事件的发生情况，可作为筛选高危病例的一个指标。
목적：탐토혈장N말단-뇌납태전체(NT-proBNP)수평여불은정형심교통(UAP)환자근기예후적관계。방법：인흉통주원병경관상동맥조영검사학진위UAP적환자52례，분별검측증상발작후18h화증상완해96h혈장NT-proBNP수평，병계산차치비。대UAP환자수방30천，기록환자주요심혈관사건(MACE)적발생정황，병응용수시자공작곡선(ROC)분석차치비대UAP환자발생근기심혈관사건적예측개치。결과：발생심혈관사건환자적NT-proBNP차치비고우미발생자，차이구유통계학의의(P＜0.05)。ROC결과현시，NT-proBNP차치비위0.99시，기예측UAP환자근기발생심혈관사건적령민도화특이도분별위64.3%화81.8%。결론：NT-proBNP차치비가용래예측UAP환자근기심혈관사건적발생정황，가작위사선고위병례적일개지표。
Objective:To explore the relationships between N-terminal pro-brain natriuretic peptide (NT-proBNP) level and short-term prognosis of unstable angina pectoris (UAP). Methods:52 UAP patients were hospitalized because of chest pain and confirmed by coronary angiography. The plasma NT-proBNP level of 52 patients was respectively detected 18hafter attacksofsymptoms andremissionofsymptoms for96h, and then calculated the D-value ratio.All the patients were followed up for 30 days and recorded the occurrence of main adverse cardiovascular event (MACE). ROC curve of D-value ratio was used to analyze the predictive value of D-value ratio for MACE.Results:The D-value ratio of patients with MACE was obviously higher than that of the patients no MACE (P<0.05).According to the ROC curve, the predictive sensitivity of MACE was 64.3%and specificity was 81.8%when D-value ratio was 0.99. Conclusions:The D-value ratio of NT-proBNPcanbe usedtopredictMACEinUAP,and can be used as a markerforscreening high-risk patients.