CAJ | 학술논문

目的：观察结肠癌组织星形细胞上调基因-1(astrocyte elevated gene-1，AEG-1)的表达情况，并分析AEG-1表达与结肠癌临床病理特征的关系。方法：采用免疫组化EnVision二步法检测63例结肠癌组织和30例正常结肠黏膜AEG-1的表达情况，并分析AEG-1表达与结肠癌临床病理特征的关系。结果：63例结肠癌组织AEG-1阳性表达率为68.25%(43/63)，30例正常结肠黏膜AEG-1阳性表达率为26.67%(8/30)，结肠癌组织AEG-1阳性表达率明显高于正常结肠黏膜，差异具有统计学意义(χ2=14.192，P＜0.01)。结肠癌组织AEG-1的表达与肿瘤的分化程度和分期有关(P＜0.05)，与性别、年龄、肿瘤大小无关(P＞0.05)。结论：AEG-1在结肠癌中表达升高，其异常表达与结肠癌的发生、发展有关。
목적：관찰결장암조직성형세포상조기인-1(astrocyte elevated gene-1，AEG-1)적표체정황，병분석AEG-1표체여결장암림상병리특정적관계。방법：채용면역조화EnVision이보법검측63례결장암조직화30례정상결장점막AEG-1적표체정황，병분석AEG-1표체여결장암림상병리특정적관계。결과：63례결장암조직AEG-1양성표체솔위68.25%(43/63)，30례정상결장점막AEG-1양성표체솔위26.67%(8/30)，결장암조직AEG-1양성표체솔명현고우정상결장점막，차이구유통계학의의(χ2=14.192，P＜0.01)。결장암조직AEG-1적표체여종류적분화정도화분기유관(P＜0.05)，여성별、년령、종류대소무관(P＞0.05)。결론：AEG-1재결장암중표체승고，기이상표체여결장암적발생、발전유관。
Objective:To observe the expression of astrocyte elevated gene-1 (AEG-1) in colonic carcinoma and analyze the relationship between AEG-1 and clinicopathological characteristics of colonic carcinoma.Methods:EnVision immunohistochemical method was used to detect the expression of AEG-1 in 63 cases colonic carcinoma and 30 cases normal colonic mucosa;and then the relationship between AEG-1 and clinicopathological characteristics of colonic carcinoma was analyzed.Results:In 63 cases colonic carcinoma, the positive expression rate ofAEG-1 was 68.25%(43/63);In 30 cases normal colonic mucosa, the positive expression rate of AEG-1 was 26.67%(8/30);the positive expression rate of AEG-1 in colonic carcinoma was obviously higher than that in normal colonic mucosa (χ2=14.192, P<0.01). The expressionofAEG-1incoloniccarcinomawasrelatedtodifferentiateddegreeandTNMstageofcoloniccarcinoma(P<0.05);but had no relations with sex, age and tumor size (P>0.05). Conclusions:Upregulation of AEG-1 expression in colonic carcinomaiscloselyrelatedwithdevelopmentofcolonic carcinoma.